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Click here for Trumenba® (meningococcal group B vaccine (recombinant, adsorbed)) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

Meningococcal group B vaccine

Trumenba (meningococcal group B vaccine (recombinant, adsorbed)) is indicated for active immunisation of individuals 10 years and older to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroup B1

Trumenba is a vaccine composed of 2 recombinant lipidated factor H binding protein (fHbp) variants. fHbp is found on the surface of meningococcal bacteria and is essential for bacteria to avoid host immune defences.1
fHbp variants segregate into 2 immunologically distinct subfamilies, A and B, and over 91%** of MenB strains express sufficient levels of fHbp subfamily A or B to  be killed by Trumenba induced antibodies1
Vaccinate with Trumenba to help protect adolescents and young adults from MenB disease.1

**A survey of over 2,150 different invasive meningococcal serogroup B isolates collected from 2000-2014 in 7 European countries, the US and Canada demonstrated that over 91% of all meningococcal serogroup B isolates expressed sufficient levels of fHbp to be susceptible to bactericidal killing by vaccine-induced antibodies.1​​​​​​
​​​​​​​

Trumenba offers two dosing schedules for adolescents and young adults1


Dosing Schedules

2-dose schedule1
This includes 2 doses (0.5ml each) administered 6 months apart.

3-dose schedule1
This includes 2 doses (0.5ml each) administered at least 1 months apart, followed by a third dose at least 4 months after the second dose.


Dosing considerations1

  • A booster dose should be considered following either dosing regimen for individuals at continued risk of IMD.
  • The use of this vaccine should be in accordance with official recommendations1

Trumenba can be co-administered concomitantly with​​​​​​​:

  • Quadrivalent Human Papillomavirus vaccine (HPV4)
  • Meningococcal Serogroups A, C, W, Y conjugate vaccine (MenACWY)
  • Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed (Tdap)
  • Tetanus Toxoid, Reduced Diphtheria Toxoid, Acellular Pertussis, and Inactivated Poliovirus Vaccine (TdaP-IPV)

References​​
  1. Trumenba. Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/2670​​​​​​​
PP-TRU-GBR-0130. March 2021

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PP-PFE-GBR-2688. December 2020

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