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Click here for Xalkori® (crizotinib) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

Efficacy

The efficacy and safety of XALKORI have been evaluated in two trials, PROFILE 1001 and PROFILE 1014.2,3

Clinical Trial Programmes 

PROFILE 1001 
ROS1 + NSCLC

PROFILE 1001 : clinical trial efficacy outcomes

Learn More

PROFILE 1014 
ALK + NSCLC

PROFILE 1014 : clinical trial efficacy outcomes

Learn More

References
  1. XALKORI Summary of Product Characteristics
  2. Shaw AT, Riely GJ, Bang YJ, et al. Crizotinib in ROS1-rearranged advanced non-small cell lung cancer (NSCLC): updated results, including overall survival, from PROFILE 1001. Ann Oncol. 2019;30(7):1121-6.
  3. Solomon BJ, Mok T, Kim DW, et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014;371(23):2167-77.
PP-XLK-GBR-1164. March 2021

Indication

XALKORI as a monotherapy is indicated for:1

  • The first-line treatment of adults with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC)
  • The treatment of adults with previously treated anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC)
  • The treatment of adults with ROS1-positive advanced non-small cell lung cancer (NSCLC)

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