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Click here for Xalkori® (crizotinib) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

DURUISSEAUX et al. 2017

The OS with XALKORI in unselected ALK+ NSCLC patients was assessed.1​​​​​​​

Median OS of 89.6 months for patients receiving next-generation ALK inhibitors after progression on XALKORI was significantly longer than with XALKORI followed by other systemic therapies (28.2 months) or BSC (19.6 months) (p<0.001).1

Limitations of the analysis:1

The improved OS data may have been due to biases in patient selection, OR specific tumour biology and high sensitivity to ALK inhibition, rather than a direct effect of treatment strategies.
Patients receiving next-generation ALK inhibitors tended to be younger, more frequently exhibited PFS on XALKORI ≥median, more frequently received XALKORI beyond progressive disease, and more frequently exhibited cerebral progression than patients receiving subsequent drugs other than next-generation ALK inhibitors.

5.0% of patients received XALKORI in first line, 54.1% in second line and 40.9% in later lines of therapy (≥2).
Next-generation ALK inhibitors administered: 57 patients received ceritinib, 19 alectinib, 5 ceritinib then alectinib, 1 ceritinib then lorlatinib, 2 alectinib then ceritinib. Lorlatinib is an investigational compound.
The mean time from diagnosis of advanced disease to initiation of XALKORI was 13.9 months (95% CI: 12.4–15.5).

OS from diagnosis according to systemic treatments initiated following progression on XALKORI (n=263)*1

Adapted from Duruisseuax M, et al. Oncotarget, 2017;8(13):21903-17.1

*Median duration of follow-up was 44.4 months (95% Ci: 40.6-47.5).

ALK inhibitors1

The survival rates reported here in a large population treated with crizotinib then next-generation ALK inhibitors could represent an interesting benchmark for ongoing clinical trials assessing how best to sequence the available ALK inhibitors.


ALKi, ALK inhibitor; BSC, best supportive care; PFS, progression-free survival.​​​​​​​
References
  1. Duruisseaux M, Besse B, Cadranel J, et al. Overall survival with crizotinib and next-generation ALK inhibitors in ALK-positive non-small-cell lung cancer (IFCT-1302 CLINALK): a French nationwide cohort retrospective study. Oncotarget. 2017;8(13):21903–17.
  2. XALKORI Summary of Product Characteristics.
PP-XLK-GBR-1171. March 2021

Indication

  • XALKORI as a monotherapy is indicated for:2

    • The first-line treatment of adults with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC)
    • The treatment of adults with previously treated anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC)
    • The treatment of adults with ROS1-positive advanced non-small cell lung cancer (NSCLC)

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