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Information relating to specific disease areas aligned to Pfizer’s portfolio and other resources designed for Pfizer medicines.

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Information on how to access XELJANZ®▼ (tofacitinib citrate) prescribing information and adverse event reporting can be found at the bottom of the page.

XELJANZ in Action

An alternative MoA targeting the JAK pathway1–3

XELJANZ inhibits the effects of pro-inflammatory cytokines through intracellular targeting of the JAK pathway3

  • XELJANZ works inside the cell to inhibit inflammation by blocking JAK-dependent signalling pathways4​​​​​​​
  • This reduces the production of multiple pro-inflammatory cytokines4,5

JAK, Janus kinase; MOA, mode of action

Prescribing Information:

Xeljanz (tofacitinib citrate) Prescribing Information (Great Britain) - 5mg film-coated tablets
Xeljanz (tofacitinib citrate) Prescribing Information (Great Britain) - 10mg film-coated tablets
Xeljanz (tofacitinib citrate) Prescribing Information (Northern Ireland) -  5mg and 10mg film-coated tablets
​​​​​​​Xeljanz (tofacitinib citrate) Prescribing Information (Great Britain) -  11mg prolonged release tablets
Xeljanz (tofacitinib citrate) Prescribing Information (Northern Ireland) -  11mg prolonged release tablets

  1. XELJANZ (tofacitinib citrate) Summary of Product Characteristics.
  2. Tanaka Y, Yamaoka K. Mod Rheumatol 2012; 23:415–424.
  3. Fleischmann R. Curr Opin Rheumatol 2012; 24:335–341.
  4. O’Shea JJ et al. Ann Rev Med 2015; 66:311–328.
  5. McInnes IB, Liew FY. Nat Clin Pract Rheumatol 2005; 1:31–39
PP-XEL-GBR-3126. August 2021

Announcement Title

XELJANZ Risk Minimisation Programme (RMP) materials, including a Patient Alert Card, Prescriber Checklists and a Prescriber Brochure are available from Patients treated with XELJANZ should be given the Patient Alert Card.

How XELJANZ works

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PP-PFE-GBR-3863. November 2021



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