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XELJANZ® (tofacitinib citrate) Prescribing Information and Maxtrex (methotrexate) Prescribing Information. Adverse event reporting can be found at the bottom of the page.
Tofacitinib should only be used if no suitable treatment alternatives are available in patients:
These risks are considered class effects and relevant across all approved indications of JAKi in inflammatory and dermatologic diseases.
The following data is from post-hoc analyses and therefore when interpreting this data, the limitations of post-hoc analyses should be taken into consideration.
For patients with moderately to severely active ulcerative colitis, onset of action is an important consideration when choosing appropriate therapy to provide timely symptomatic relief1
Based on post-hoc analyses of daily patient diary data from the OCTAVE induction studies:
*Relates to results from a post-hoc analysis, consideration should be made for multiple testing and inclusion of unadjusted p-values when interpreting data.
Post-hoc analysis of pooled data from Induction 1 and 2 trials. Daily Mayo stool frequency and rectal bleeding subscores were calculated using patient diary data collected daily during the first 15 days of induction therapy. Partial Mayo Score subscore data were first collected at Day 15.
References
These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.
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*The ABPI Code definition for healthcare professional is members of the medical, dental, pharmacy and nursing professionals and any other persons who in the course of their professional activities may administer, prescribe, purchase, recommend or supply a medicine.
PP-UNP-GBR-7812. January 2024