Information on how to access XELJANZ®▼ (tofacitinib citrate) prescribing information and adverse event reporting can be found at the bottom of the page.
The following data is from post-hoc analyses and therefore when interpreting this data, the limitations of post-hoc analyses should be taken into consideration.
For patients with moderately to severely active ulcerative colitis, onset of action is an important consideration when choosing appropriate therapy to provide timely symptomatic relief1
Based on post-hoc analyses of daily patient diary data from the OCTAVE induction studies:
Mean change from baseline rectal bleeding subscore of -0.30 vs -0.14; p<0.01
Mean change from baseline stool frequency subscore of -0.27 vs -0.11; p<0.01
*Relates to results from a post-hoc analysis, consideration should be made for multiple testing and inclusion of unadjusted p-values when interpreting data.
†Post-hoc analysis of pooled data from Induction 1 and 2 trials. Daily Mayo stool frequency and rectal bleeding subscores were calculated using patient diary data collected daily during the first 15 days of induction therapy. Partial Mayo Score subscore data were first collected at Day 15.
‡Percentage of patients with reduction from baseline Mayo rectal bleeding subscore >1 excludes patients with baseline Mayo rectal bleeding subscore = 0
§Percentage of patients with reduction from baseline Mayo stool frequency subscore of >1 excludes patients with baseline Mayo stool frequency subscore = 0
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XELJANZ Risk Minimisation Programme (RMP) materials, including a Patient Alert Card, Prescriber Checklists and a Prescriber Brochure are available from https://www.medicines.org.uk/emc/. Patients treated with XELJANZ should be given the Patient Alert Card.
These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.
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