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AboutAboutHow XELJANZ worksXELJANZ in ActionCytokinesSignalling PathwaysDosingDosingDosing in RADosing in UCDosing in PsADosing in pJIA and jPsADosing in ASSpecial Warnings & PrecautionsEfficacy & SafetyEfficacy & SafetySafety & TolerabilityOral SurveillanceAdverse EventsClinical Efficacy RAORAL Strategy Study DesignORAL Strategy Efficacy ResultsORAL Strategy Safety OutcomesClinical Efficacy UCOCTAVE Study DesignOCTAVE Sub GroupsOCTAVE InductionOCTAVE SustainPost-hoc AnalysesClinical Efficacy PsAOPAL Broaden & BeyondClinical Efficacy pJIA and jPsAJIA-1 Study DesignJIA-1 Efficacy ResultsJIA-1 Safety OutcomesClinical Efficacy ASASAS20/40 DataASDAS(CRP) DataReal World EvidenceReal World EvidenceReal World Evidence
Why Real-World Data?Key Characteristics of RCTs & RWEKey Strengths & Limitations
STAR-RAMalignancy Study DesignMalignancy Risk OutcomesCV Risk Study DesignCV Risk OutcomesSCQM-RAStudy DesignStudy OutcomesCorEvitas RASafety Study DesignEfficacy Study DesignOutcomesUC RWETOUR Registry (US)Honap Study (UK)Tursi Study (Italy)
Supporting ResourcesSupporting ResourcesMaterialsGRAPPA GuidelinesVideosExpert Opinions

XELJANZ® (tofacitinib citrate) Prescribing Information and Maxtrex (methotrexate) Prescribing Information. Adverse event reporting can be found at the bottom of the page.
 
 Tofacitinib should only be used if no suitable treatment alternatives are available in patients:

  • 65 years of age and older;
  • patients with history of atherosclerotic cardiovascular disease or other cardiovascular risk factors (such as current or past long-time smokers);
  • patients with malignancy risk factors (e.g. current malignancy or history of malignancy)

 These risks are considered class effects and relevant across all approved indications of JAKi in inflammatory and dermatologic diseases.

Expert opinion:
Professor Raj Sengupta

Professor Raj Sengupta is a Consultant Rheumatologist and Clinical Lead for Ankylosing Spondylitis (AS) at The Royal National Hospital for Rheumatic Diseases, Bath (RNRHD).
 
He is a member of the BSR Spondyloarthritis Special Interest Group, the BSR axSpA Biologics Guidelines Committee and a member of ASAS (Assessment of Spondyloarthritis International Society). Professor Sengupta is a medical advisor for the National Axial Spondyloarthritis Society (NASS) and is Chair of the Trustees and current Treasurer of the British Society for Spondyloarthritis (BRITSpA).
 
He has been nominated as a NICE Clinical Expert at a number of appraisals for targeted therapies in axSpA. Professor Sengupta was the recipient of the 2016 NASS Patients Choice award for the Best care provided by a Rheumatologist.
 
He is the principal investigator in several national and international clinical trials in Axial Spondyloarthritis (axSpA). He has a number of peer reviewed publications on axSpA. Professor Sengupta has been an invited speaker for axSpA at several national and international meetings.


The management of Ankylosing Spondylitis and the role of Xeljanz in its treatment.
 

Introduction to Modular AS Videos


Module 1: The Burden of Disease with Axial Spondyloarthritis and AS


Module 2: Treatment Options in AS 


Module 3: An Overview of the Evidence Base Supporting the Use of Xeljanz in AS


Module 4: A Clinicians Perspective in AS

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XELJANZ Risk Minimisation Programme (RMP) materials, including a Patient Alert Card, Prescriber Checklists and a Prescriber Brochure are available from https://www.medicines.org.uk/emc/. Patients treated with XELJANZ should be given the Patient Alert Card.
PP-XEL-GBR-4893. April 2024
Professor Raj Sengupta MBBS, PGCME, FRCP Ankylosing Spondylitis

Find out more about dosing in Ankylosing Spondylitis.

Visit Dosing in ASLoading

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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