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AboutAboutHow XELJANZ worksXELJANZ in ActionCytokinesSignalling PathwaysDosingDosingDosing in RADosing in UCDosing in PsADosing in pJIA and jPsADosing in ASSpecial Warnings & PrecautionsEfficacy & SafetyEfficacy & SafetySafety & TolerabilityOral SurveillanceAdverse EventsClinical Efficacy RAORAL Strategy Study DesignORAL Strategy Efficacy ResultsORAL Strategy Safety OutcomesClinical Efficacy UCOCTAVE Study DesignOCTAVE Sub GroupsOCTAVE InductionOCTAVE SustainPost-hoc AnalysesClinical Efficacy PsAOPAL Broaden & BeyondClinical Efficacy pJIA and jPsAJIA-1 Study DesignJIA-1 Efficacy ResultsJIA-1 Safety OutcomesClinical Efficacy ASASAS20/40 DataASDAS(CRP) DataReal World EvidenceReal World EvidenceReal World Evidence
Why Real-World Data?Key Characteristics of RCTs & RWEKey Strengths & Limitations
STAR-RAMalignancy Study DesignMalignancy Risk OutcomesCV Risk Study DesignCV Risk OutcomesSCQM-RAStudy DesignStudy OutcomesCorEvitas RASafety Study DesignEfficacy Study DesignOutcomesUC RWETOUR Registry (US)Honap Study (UK)
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XELJANZ® (tofacitinib citrate) Prescribing Information and Maxtrex (methotrexate) Prescribing Information. Adverse event reporting can be found at the bottom of the page.
 
 Tofacitinib should only be used if no suitable treatment alternatives are available in patients:

  • 65 years of age and older;
  • patients with history of atherosclerotic cardiovascular disease or other cardiovascular risk factors (such as current or past long-time smokers);
  • patients with malignancy risk factors (e.g. current malignancy or history of malignancy)

 These risks are considered class effects and relevant across all approved indications of JAKi in inflammatory and dermatologic diseases.

Expert opinion:
Professor A. V. Ramanan, FRCPCH, FRCP
An expert opinion on the role of XELJANZ® (tofacitinib citrate) in the treatment of Juvenile Idiopathic Arthritis 


Biography

Professor Ramanan is a medical advisor for Olivia’s Vision. He is also Co-Chair for the National Institute for Health Research Clinical Research Network: Children/Arthritis Research UK (ARUK) Paediatric Rheumatology Clinical Studies Group. He was awarded the British Society of Rheumatology’s Innovation in Clinical Practice Award in 2010. He was also awarded the University of Bristol Vice Chancellor’s Health Impact award in 2017 and Royal College of Physicians/NIHR CRN Award for outstanding contribution to research in 2018.

Professor Ramanan’s has published >225 articles and numerous book chapters covering a variety of topics in the field of rheumatology. He is the Co-Editor of Rheumatology and Associate Editor for the Archives of Diseases in Childhood.

He is one of the Editors of 5th Edition of Oxford Textbook of Rheumatology.

He has also led pivotal trials of Tocilizumab and Baricitinib in COVID-19 and part of the paediatric steering committee of the RECOVERY trial.

Maxtrex (methotrexate) is not approved for use in JIA.

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XELJANZ Risk Minimisation Programme (RMP) materials, including a Patient Alert Card, Prescriber Checklists and a Prescriber Brochure are available from https://www.medicines.org.uk/emc/. Patients treated with XELJANZ should be given the Patient Alert Card.
PP-XEL-GBR-4385. Feb 2024
Athimalaipet V. Ramanan, FRCPCH, FRCP

Athimalaipet V. Ramanan is a consultant pediatric rheumatologist at the Bristol Royal Hospital for Children. He is the joint lead for research (Division of Women and Children) at the Bristol Royal Hospital for Children, and Professor of Paediatric Rheumatology at the University of Bristol.

Juvenile Idiopathic Arthritis (JIA): A Clinician Perspective

In this video, watch Professor Ramanan share his views on the topic of XELJANZ in JIA.

Watch JIA: A Clinician PerspectiveLoading
Juvenile Idiopathic Arthritis

Take a look at the Xeljanz JiA-1 clinical studies by clicking below.

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Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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