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ZAVICEFTA® (ceftazidime - avibactam): For the management of serious infections in critically ill patients

ZAVICEFTA (ceftazidime and avibactam), for the treatment of patients at high risk of MDR Gram-negative infections with suspected or documented P. aeruginosa, CRE (KPC, OXA-48), and ESBL- and AmpC-producing pathogens1-4.

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ZAVICEFTA is indicated for the treatment of adult and paediatric patients aged 3 months and older with the following infections:1*

Complicated intra-abdominal infection (cIAI)
Complicated urinary tract infection (cUTI), including pyelonephritis
Hospital‑acquired pneumonia (HAP), including ventilator‑associated pneumonia (VAP)
​​​​​​​
Treatment of adult patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above. ZAVICEFTA is also indicated for the treatment of infections due to aerobic Gram‑negative organisms in adult patients with limited treatment options.
*Consideration should be given to the official guidance on the appropriate use of antibacterial agents.1
†Data support the use of ZAVICEFTA in patients with Limited Treatment Options for the treatment of bacteraemia, cSSTI, BSI, meningitis due to KPC and OXA‑48 resistance mechanisms, and MDR Pseudomonas.7-12


Learn more from experts talking about ZAVICEFTA for the treatment of hospital-acquired pneumonia (HAP), including ventilator associated pneumonia (VAP)1

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Access results of ZAVICEFTA Phase III clinical trials in adult patients with cUTI, cIAI or HAP/VAP

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Learn more about the safety data of ZAVICEFTA from 4 Phase III clinical trials.

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Learn about ZAVICEFTA dosing across patient populations, preparation & administration, and shelf life & storage

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Patient Risk Factors

Identifying patients at risk of MDR Gram-negative infections is vital for appropriate selection of adequate, early antimicrobial therapy to reduce the risk of fatal outcomes5.

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Pathogen coverage

ZAVICEFTA has broad spectrum coverage against Gram-negative pathogens including in vitro activity against MDR P.aeruginosa, CRE, including KPC- and OXA-48 producing strains, and ESBL- and AmpC-producing bacteria1-4.

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Antimicrobial Stewardship

Access our resources for implementation of an Antimicrobial Stewardship Programme and learn more about Pfizer initiatives to fight AMR

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Abbreviations

cUTI, complicated urinary tract infection; cIAI, complicated intra-abdominal infection; HAP, hospital-acquired pneumonia; VAP, ventilator-associated pneumonia; MDR, multi-drug resistant; BL/BLI, β-lactam/β-lactamase inhibitors; CRE, carbapenem-resistant Enterobacteriaceae; KPC, Klebsiella pneumoniae carbapenemase; MBL, metallo-β-lactamase; OXA, oxacillinase; ESBL, extended-spectrum β-lactamase, BSI, bloodstream infection; cSSTI, complicated skin and soft tissue.

References
  1. ​​​​​​​ZAVICEFTA. Summary of Product Characteristics
  2. Liscio JL, et al. Int J Antimicrob Agents 2015;46:266–7
  3. Nicolau DP, et al. J Antimicrob Chemother 2015;70:2862–9
  4. Mazuski JE, et al. Surg Infect 2017;18:1–76 
  5. Bonine NG, et al. Am J Med Sci 2019;357:102–10​​​​​​​
  6. Morris, AC. JECCM 2018;2:101-01.
  7. Tumbarello M, et al. Clin Infect Dis 2012;55:943–50
  8. Caston JJ, et al. J Infect Dis 2017;59:118–23
  9. Van Duin D, et al. J Clin Infect Dis 2018;66:163–71
  10. Sousa A, et al. Antimicrob Chemother 2018;73:3170–5
  11. Temkin E, et al. Antimicrob Agents Chemother 2017;61:e01964-16
  12. Shields K, et al. Antimicrob Agents Chemother 2017;61:e00883-17
PP-ZVA-GBR-0836. June 2021

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