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A broad spectrum, third-generation antipseudomonal cephalosporin with a well characterized efficacy and tolerability profile1,2.
A novel β-lactamase inhibitor, which allows ceftazidime to maintain activity in presence of certain resistance mechanisms1,2.
Watch animation on Zavicefta mechanism of action
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Gram-negative pathogen coverage by indication5-9*
Content |
cIAIs |
cUTIs |
HAP/VAP |
---|---|---|---|
Citrobacter freundii |
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Enterobacter cloacae |
|||
Escherichia coli |
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Klebsiella oxytoca |
|||
Klebsiella pneumoniae |
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Proteus mirabilis |
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Pseudomonas aeruginosa |
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Serratia marcescens |
*In vitro data indicate that the following species are not susceptible to ZAVICEFTA: Staphylococcus aureus (methicillin-susceptible and methicillin-resistant strains), anaerobes, Enterococcus spp., Stenotrophomonas maltophilia and Acinetobacter spp.
Read more about patient risk factors in HAP/VAP,cUTI and cIAI
Abbreviations
cUTI, complicated urinary tract infection, cIAI, complicated intra-abdominal infection; HAP, hospital-acquired pneumonia; VAP, ventilator-associated pneumonia; MDR, multi-drug resistant; BL/BLI, β-lactam/β-lactamase inhibitors; CRE, carbapenem-resistant Enterobacteriaceae; KPC, Klebsiella pneumoniae carbapenemase; MBL, metallo-β-lactamase; OXA, oxacillinase; ESBL, extended-spectrum β-lactamase; CrCl, creatinine clearance; ELF, epithelial lining fluid; AMR, Antimicrobial Resistance; MIC, minimum inhibitory concentration; EUCAST, European Committee on Antimicrobial Susceptibility Testing;
Prescribing information
Zavicefta (ceftazidime and avibactam) 2g/0.5 g Powder for Concentrate for Solution for Infusion
Meronem® (meropenem triydrate) IV 1g
Meronem® (meropenem triydrate) IV 500mg
Tazocin® (piperacillin sodium, tazobactam sodium) 2g/0.25g Powder for Solution for Infusion
Tazocin® (piperacillin sodium, tazobactam sodium) 4g/0.5g Powder for Solution for Infusion
Gentamicin (gentamicin sulfate) 40 mg/ml Injection
Legal Category: Prescription Only Medicine (POM)
NHS Price: 5 vial £20.00
Click here for the Summary of Product Characteristics
Ciprofloxacin (ciprofloxacin lactate) 2 mg/ml Solution for Infusion
Legal Category: Prescription Only Medicine (POM)
NHS Price: 10 bag £200.00
Click here for the Summary of Product Characteristics
Amikacin (amikacin sulfate) 500mg/2ml solution for injection
Legal Category: Prescription Only Medicine (POM)
NHS Price: 5 vial pack £60.00
Click here for the Summary of Product Characteristics
Tobramycin (tobramycin)
Tobramycin 240mg/6ml solution for injection
Legal Category: Prescription Only Medicine (POM)
Basic NHS Cost: 1 vial £19.20
Click here for the Summary of Product Characteristics
Tobramycin 80mg/2ml solution for injection
Legal Category: Prescription Only Medicine (POM)
Basic NHS Cost: 5 vial £20.80
Click here for the Summary of Product Characteristics
KOL Videos - Zavicefta
View safety profile
Infectious Disease Physician at Hospital Clinic in Barcelona, Spain, summarises key ZAVICEFTA data against other β-lactam/β-lactamase inhibitor combinations. He discusses ZAVICEFTA’s in vitro activity and broad-spectrum coverage against MDR P. aeruginosa and Enterobacteriaceae (including Klebsiella pneumoniae, Escherichia coli and ESBL-producing strains).
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