Information on how to access prescribing information and adverse event reporting can be found at the bottom of the page.
For patients requiring treatment of infections due to resistant, aerobic Gram-negative bacteria
ZAVICEFTA® for the treatment of patients with suspected or documented Enterobacteriaceae and P. aeruginosa infection with resistance to ESBLs, KPC & OXA-48 carbapenemases and AmpC enzymes1–4
Ceftazidime
A broad spectrum, third-generation antipseudomonal cephalosporin with a well characterized efficacy and tolerability profile1,2.
Avibactam
A novel β-lactamase inhibitor, which allows ceftazidime to maintain activity in presence of certain resistance mechanisms1,2.
The combination of ceftazidime and avibactam provides broad spectrum Gram-negative pathogen coverage
Watch animation on Zavicefta mechanism of action
Header
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Gram-negative pathogen coverage by indication5-9*
Content |
cIAIs |
cUTIs |
HAP/VAP |
|---|---|---|---|
Citrobacter freundii |
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Enterobacter cloacae |
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Escherichia coli |
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Klebsiella oxytoca |
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Klebsiella pneumoniae |
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Proteus mirabilis |
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Pseudomonas aeruginosa |
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Serratia marcescens |
*In vitro data indicate that the following species are not susceptible to ZAVICEFTA: Staphylococcus aureus (methicillin-susceptible and methicillin-resistant strains), anaerobes, Enterococcus spp., Stenotrophomonas maltophilia and Acinetobacter spp.
Explore more
Identifying patients at risk of MDR Gram-negative infections is vital for appropriate selection of adequate, early antimicrobial therapy to reduce the risk of fatal outcomes10
Read more about patient risk factors in HAP/VAP,cUTI and cIAI
Abbreviations
cUTI, complicated urinary tract infection, cIAI, complicated intra-abdominal infection; HAP, hospital-acquired pneumonia; VAP, ventilator-associated pneumonia; MDR, multi-drug resistant; BL/BLI, β-lactam/β-lactamase inhibitors; CRE, carbapenem-resistant Enterobacteriaceae; KPC, Klebsiella pneumoniae carbapenemase; MBL, metallo-β-lactamase; OXA, oxacillinase; ESBL, extended-spectrum β-lactamase; CrCl, creatinine clearance; ELF, epithelial lining fluid; AMR, Antimicrobial Resistance; MIC, minimum inhibitory concentration; EUCAST, European Committee on Antimicrobial Susceptibility Testing;
Prescribing information
Zavicefta (ceftazidime and avibactam) 2g/0.5 g Powder for Concentrate for Solution for Infusion
Meronem® (meropenem triydrate) IV 1g
Meronem® (meropenem triydrate) IV 500mg
Tazocin® (piperacillin sodium, tazobactam sodium) 2g/0.25g Powder for Solution for Infusion
Tazocin® (piperacillin sodium, tazobactam sodium) 4g/0.5g Powder for Solution for Infusion
Gentamicin (gentamicin sulfate) 40 mg/ml Injection
Legal Category: Prescription Only Medicine (POM)
NHS Price: 5 vial £20.00
Click here for the Summary of Product Characteristics
Ciprofloxacin (ciprofloxacin lactate) 2 mg/ml Solution for Infusion
Legal Category: Prescription Only Medicine (POM)
NHS Price: 10 bag £200.00
Click here for the Summary of Product Characteristics
Amikacin (amikacin sulfate) 500mg/2ml solution for injection
Legal Category: Prescription Only Medicine (POM)
NHS Price: 5 vial pack £60.00
Click here for the Summary of Product Characteristics
Tobramycin (tobramycin)
Tobramycin 240mg/6ml solution for injection
Legal Category: Prescription Only Medicine (POM)
Basic NHS Cost: 1 vial £19.20
Click here for the Summary of Product Characteristics
Tobramycin 80mg/2ml solution for injection
Legal Category: Prescription Only Medicine (POM)
Basic NHS Cost: 5 vial £20.80
Click here for the Summary of Product Characteristics
- ZAVICEFTA. Summary of Product Characteristics
- Liscio JL, et al. Int J Antimicrob Agents 2015;46:266–71
- Nicolau DP, et al. J Antimicrob Chemother 2015;70:2862–9
- Mazuski JE, et al. Surg Infect 2017;18:1–76
- Bassetti M, et al. Exp Rev Anti Infect Ther 2017;15:55–65
- Miller BM, et al. Am J Infect Control 2016;44:134–7
- De Waele J, et al. Intensive Care Med 2018;44:189–96
- Albur M, et al. Ann Clin Microbiol Antimicrob 2016;15:23
- Harris AD, et al. Emerg Infect Dis 2007;13:1144–9
- Bonine NG, et al. Am J Med Sci 2019;357:102–10
Access case studies and videos
KOL Videos - Zavicefta
Learn more about the tolerability data of ZAVICEFTA from four Phase III clinical trials.
View safety profile
Alex Soriano
Infectious Disease Physician at Hospital Clinic in Barcelona, Spain, summarises key ZAVICEFTA data against other β-lactam/β-lactamase inhibitor combinations. He discusses ZAVICEFTA’s in vitro activity and broad-spectrum coverage against MDR P. aeruginosa and Enterobacteriaceae (including Klebsiella pneumoniae, Escherichia coli and ESBL-producing strains).
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