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Adverse event reporting can be found at the bottom of the page
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Information on how to access prescribing information and adverse event reporting can be found towards the bottom of the page.
A broad spectrum, third-generation antipseudomonal cephalosporin with a well characterized efficacy and tolerability profile1,2.
A β-lactamase inhibitor, which allows ceftazidime to maintain activity in presence of certain resistance mechanisms1,2.
Gram-negative pathogen coverage by indication5-9*
| Content | cIAIs | cUTIs | HAP/VAP |
|---|---|---|---|
| Citrobacter freundii |  |
||
| Enterobacter cloacae |
|
|
|
| Escherichia coli |
|
|
|
| Klebsiella oxytoca |
|
||
| Klebsiella pneumoniae |
|
|
|
| Proteus mirabilis |
|
|
|
| Pseudomonas aeruginosa | |
|
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| Serratia marcescens |
|
*In vitro data indicate that the following species are not susceptible to ZAVICEFTA: Staphylococcus aureus (methicillin-susceptible and methicillin-resistant strains), anaerobes, Enterococcus spp., Stenotrophomonas maltophilia and Acinetobacter spp.
Read more about patient risk factors in HAP/VAP,cUTI and cIAI
Abbreviations
cUTI, complicated urinary tract infection, cIAI, complicated intra-abdominal infection; HAP, hospital-acquired pneumonia; VAP, ventilator-associated pneumonia; MDR, multi-drug resistant; BL/BLI, β-lactam/β-lactamase inhibitors; CRE, carbapenem-resistant Enterobacteriaceae; KPC, Klebsiella pneumoniae carbapenemase; MBL, metallo-β-lactamase; OXA, oxacillinase; ESBL, extended-spectrum β-lactamase; CrCl, creatinine clearance; ELF, epithelial lining fluid; AMR, Antimicrobial Resistance; MIC, minimum inhibitory concentration; EUCAST, European Committee on Antimicrobial Susceptibility Testing;
Prescribing Information
Click here for ZAVICEFTA® (ceftazidime and avibactam) Prescribing Information
Click here for MERONEM® Prescribing Information
Click here for TAZOCIN® (piperacillin sodium, tazobactam sodium) Prescribing Information
Click here for AMIKACIN (amikacin sulfate) Prescribing Information
Click here for TOBRAMYCIN (tobramycin) Prescribing Information
References
Infectious Disease Physician at Hospital Clinic in Barcelona, Spain, summarises key ZAVICEFTA data against other β-lactam/β-lactamase inhibitor combinations. He discusses ZAVICEFTA’s in vitro activity and broad-spectrum coverage against MDR P. aeruginosa and Enterobacteriaceae (including Klebsiella pneumoniae, Escherichia coli and ESBL-producing strains).
Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search
for MHRA Yellow Card in Google Play or Apple App Store
Adverse events should also be reported to Pfizer Medical Information on 01304 616161
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