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Overall Risk Factors
HAP/VAP Patient Profile
cIAI Patient Profile
cUTI Patient Profile
Risk factors for MDR Gram-negative infections2-6
Early adequate antibacterial therapy is crucial for patients with serious Gram-negative infections8,9
Access dosing guide
View Phase III trial results
Footnotes:
**Early treatment must consider patient risk factors as well as local epidemiology.8
*30-day mortality rate among patients with P. aeruginosa bacteraemia who received delayed effective antimicrobial therapy’.10
†30-day mortality among 909 patients with BSIs caused by ESBL-producing K. pneumoniae (n=222) and E. coli (n=687). 11
ⱡ28-day mortality among 205 patients with BSIs caused by carbapenemase-producing K. pneumoniae (KPC and/or VIM). 12
§30-day mortality among 40 patients with BSIs caused by OXA-48 -producing Enterobacteriaceae.13
IIOverall mortality among 53 patients with BSIs caused by KPC-producing K. pneumoniae.14
Abbreviations:
cUTI, complicated urinary tract infection, cIAI, complicated intra-abdominal infection; HAP, hospital-acquired pneumonia; VAP, ventilator-associated pneumonia; MDR, multi-drug resistant; BL/BLI, β-lactam/β-lactamase inhibitors; CRE, carbapenem-resistant Enterobacteriaceae; KPC, Klebsiella pneumoniae carbapenemase; K. pneumoniae, Klebsiella pneumoniae; MBL, metallo-β-lactamase; OXA, oxacillinase; ESBL, extended-spectrum β-lactamase; P. aeruginosa, Pseudomonas aeruginosa; CrCl, creatinine clearance; AMR, Antimicrobial Resistance; CVC central venous catheter; ICU intensive care unit. AE, adverse event; CE, clinically evaluable; CI, confidence interval; cMITT, clinically modified intention-to-treat; TOC, test of cure;
Prescribing information
Zavicefta (ceftazidime and avibactam) 2g/0.5 g Powder for Concentrate for Solution for Infusion
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Professor Francesco G. De Rosa, Prof. of Infectious Diseases (Italy, Professor Philip Montravers, Anaestheisa and Critical Care Medicine (France) and Dr Paula Ramirez, Critical Care Department (Spain) discuss high-risk patients and early treatment of patients with suspected MDR Gram-negative infections in their clinical practice, and their experience using ZAVICEFTA.
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