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ZAVICEFTA® (ceftazidime-avibactam): Broad-spectrum Gram-negative coverage with consistent dosing across indications1–4

Dosing Guide Preparation Guide Shelf life and Storage
Adult Patients Paediatric Patients

ZAVICEFTA (ceftazidime-avibactam) has consistent dosing across indications1.

No dose adjustments required in the elderly, patients with mild renal impairment (estimated CrCl >50 to ≤80 mL/min) and those with hepatic impairment1

Table 1. Recommended dose for adult patients with estimated CrCL* > 50mL/min1

Table 1 footnotes:
§ The total duration shown may include intravenous ZAVICEFTA followed by appropriate oral therapy.
║There is very limited experience with the use of ZAVICEFTA for more than 14 days.
* The dose of ZAVICEFTA in patients with estimated CrCL ≤50 mL/min should be adjusted according to recommended doses. CrCL estimated using the Cockcroft-Gault formula.
† To be used in combination with metronidazole when anaerobic pathogens are known or suspected to be contributing to the infectious process.
‡ To be used in combination with an antibacterial agent active against Gram-positive pathogens when these are known or suspected to be contributing to the infectious process.

No dosage adjustment is required in:

  • The elderly
  • Patients with mild renal impairment (estimated CrCL from >50 to ≤80 mL/min)
  • Patients with hepatic impairment

Table 2. Recommended dose adjustments in adult patients with estimated CrCL* ≤ 50 mL/min1​​​​​​​

Table 2 footnotes:
* CrCL estimated using the Cockcroft-Gault formula.
† Dose recommendations are based on pharmacokinetic modelling.
​​​​​​​‡ Ceftazidime and avibactam are removed by haemodialysis. Dosing of ZAVICEFTA on haemodialysis days should occur after completion of haemodialysis.

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Access results of ZAVICEFTA Phase III clinical trials in adult patients with cUTI, cIAI or HAP/VAP

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Abbreviations

cIAI, complicated intra-abdominal infection; CrCL, creatinine clearance; cUTI, complicated urinary tract infection; ESRD, end stage renal disease; HAP, hospital-acquired pneumonia; LTO, limited treatment options; VAP, ventilator-associated pneumonia; ELF, epithelial lining fluid; AMR, Antimicrobial Resistance; MIC, minimum inhibitory concentration; EUCAST, European Committee on Antimicrobial Susceptibility Testing.

References
  1. ZAVICEFTA. Summary of Product Characteristics
  2. Liscio JL, et al. Int J Antimicrob Agents 2015;46:266–7
  3. Nicolau DP, et al. J Antimicrob Chemother 2015;70:2862–9
  4. ​​​​​​​Mazuski JE, et al. Surg Infect 2017;18:1–76
PP-ZVA-GBR-1411. March 2022

Learn more about the tolerability data of ZAVICEFTA from four Phase III clinical trials.

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PK/PD attributes of ceftazidime–avibactam in patients

Federico Pea, Professor of Pharmacology at the University of Bologna, Italy, presents the 'PK/PD attributes of ceftazidime–avibactam in patients'. 

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PP-PFE-GBR-3863. November 2021

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