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ZAVICEFTA® (ceftazidime-avibactam): Broad-spectrum Gram-negative coverage with consistent dosing across indications1–4
ZAVICEFTA (ceftazidime-avibactam) has consistent dosing across indications1.
No dose adjustments required in the elderly, patients with mild renal impairment (estimated CrCl >50 to ≤80 mL/min) and those with hepatic impairment1
Table 1. Recommended dose for adult patients with estimated CrCL* > 50mL/min1
Table 1 footnotes:
§ The total duration shown may include intravenous ZAVICEFTA followed by appropriate oral therapy.
║There is very limited experience with the use of ZAVICEFTA for more than 14 days.
* The dose of ZAVICEFTA in patients with estimated CrCL ≤50 mL/min should be adjusted according to recommended doses. CrCL estimated using the Cockcroft-Gault formula.
† To be used in combination with metronidazole when anaerobic pathogens are known or suspected to be contributing to the infectious process.
‡ To be used in combination with an antibacterial agent active against Gram-positive pathogens when these are known or suspected to be contributing to the infectious process.
No dosage adjustment is required in:
- The elderly
- Patients with mild renal impairment (estimated CrCL from >50 to ≤80 mL/min)
- Patients with hepatic impairment
Table 2. Recommended dose adjustments in adult patients with estimated CrCL* ≤ 50 mL/min1
Table 2 footnotes:
* CrCL estimated using the Cockcroft-Gault formula.
† Dose recommendations are based on pharmacokinetic modelling.
‡ Ceftazidime and avibactam are removed by haemodialysis. Dosing of ZAVICEFTA on haemodialysis days should occur after completion of haemodialysis.
Explore more
Access results of ZAVICEFTA Phase III clinical trials in adult patients with cUTI, cIAI or HAP/VAP
REPROVE Phase III trial (HAP and VAP)
Access case studies and videos
Abbreviations
cIAI, complicated intra-abdominal infection; CrCL, creatinine clearance; cUTI, complicated urinary tract infection; ESRD, end stage renal disease; HAP, hospital-acquired pneumonia; LTO, limited treatment options; VAP, ventilator-associated pneumonia; ELF, epithelial lining fluid; AMR, Antimicrobial Resistance; MIC, minimum inhibitory concentration; EUCAST, European Committee on Antimicrobial Susceptibility Testing.
- ZAVICEFTA. Summary of Product Characteristics
- Liscio JL, et al. Int J Antimicrob Agents 2015;46:266–7
- Nicolau DP, et al. J Antimicrob Chemother 2015;70:2862–9
- Mazuski JE, et al. Surg Infect 2017;18:1–76
Zavicefta® (ceftazidime and avibactam)
Great Britain
Zavicefta®(ceftazidime and avibactam) 2g/0.5 g Powder for Concentrate for Solution for Infusion
Northern Ireland
Zavicefta®(ceftazidime and avibactam) 2g/0.5 g Powder for Concentrate for Solution for Infusion
Zyvox® (linezolid)
Zyvox (linezolid) 2mg/ml Solution for Infusion
Zyvox (linezolid) 600mg Film-Coated Tablets
Zyvox (linezolid) 100mg/5ml Granules for Oral Suspension
Daptomycin
Great Britain
Daptomycin 350mg Powder for solution for injection/infusion
Daptomycin 500mg Powder for solution for injection/infusion
Northern Ireland
Daptomycin 350 & 500mg powder for solution for injection/infusion
Learn more about the tolerability data of ZAVICEFTA from four Phase III clinical trials.
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AMS Resources
PK/PD attributes of ceftazidime–avibactam in patients
Federico Pea, Professor of Pharmacology at the University of Bologna, Italy, presents the 'PK/PD attributes of ceftazidime–avibactam in patients'.
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