This site contains promotional information intended only for healthcare professionals resident in the United Kingdom

Visit Pfizer Medical site

Menu

Close

Sign InLog Out
  • EN
Single LinkDropdownLabelLinkLinkLinkLinkLinked DropdownLabelLinkLinkLinkLinkMega MenuHeading

Example of description text sitting alongside header

LabelLinkLinkLinkLinkLabelLinkLinkLinkLinkLabelLinkLinkLinkLink
Linked Mega MenuHeading

Example of description text sitting alongside header

LabelLinkLinkLinkLinkLabelLinkLinkLinkLinkLabelLinkLinkLinkLink
EN - EnglishSelect a languageLanguagesEN - EnglishFR - Françias

Menu

Close

Sign InLog Out
  • EN
Single LinkDropdownLabelLinkLinkLinkLinkLinked DropdownLabelLinkLinkLinkLinkMega MenuHeading

Example of description text sitting alongside header

LabelLinkLinkLinkLinkLabelLinkLinkLinkLinkLabelLinkLinkLinkLink
Linked Mega MenuHeading

Example of description text sitting alongside header

LabelLinkLinkLinkLinkLabelLinkLinkLinkLinkLabelLinkLinkLinkLink
EN - EnglishSelect a languageLanguagesEN - EnglishFR - Françias
Search

Menu

Close

Sign In or RegisterLog Out
Pfizer MedicinesTherapy AreasExplore ContentEventsVideosMaterialsFeatured ArticlesLet’s ConnectSupplyAlliance HealthcareOff-contract claims

Adverse event reporting can be found at the bottom of the page

Menu

Close

AboutAboutPathogen CoveragePatient Risk FactorsAntimicrobial Subscription Model PilotDosingDosingDosingPreparation GuideShelf Life and StorageEfficacy & SafetyEfficacy & SafetyMechanism of ActionREPROVE Phase III trial(HAP/VAP)RECLAIM Phase III trial(cIAI)RECAPTURE Phase III trial(cUTI)REPRISE Phase III trial(cIAI and cUTI)Safety and TolerabilityEfficacy and Safety Data for Paediatric PatientsSupport & ResourcesSupport & ResourcesAMS ResourcesSepsisWebinars (Live and On-demand)KOL Videos - ZaviceftaKOL Videos - Gram-negativeKOL Videos - Clinical experienceVideosMaterials

Information on how to access prescribing information and adverse event reporting can be found towards the bottom of the page.

ZAVICEFTA® (ceftazidime-avibactam): For the treatment of adult and paediatric patients aged 3 months and older at high risk of MDR Gram-negative infections1

ZAVICEFTA is indicated for the treatment of adult and paediatric patients aged 3 months and older with the following infections:1

- Complicated urinary tract infection (cUTI),  including pyelonephritis
- Complicated intra-abdominal infection (cIAI)
- Hospital-acquired pneumonia, including ventilator-associated pneumonia (HAP/VAP)
- Infections due to aerobic Gram-negative organisms in patients with limited treatment options†

ZAVICEFTA demonstrated similar effectiveness to comparator therapies (meropenem or cefepime) when assessed in paediatric trials*2,3

ZAVICEFTA has a similar safety and tolerability profile in paediatric patients aged 3 months and older with cIAI and cUTI to that observed in adults*1-3

The safety assessment in paediatric patients is based on data from two trials in which 61 patients with cIAI and 67 patients with cUTI aged 3 months to < 18 years received ZAVICEFTA1

Most common adverse reactions (>3%) for ZAVICEFTA were vomiting, diarrhoea, rash, and infusion site phlebitis2,3

Low rates of discontinuation due to adverse effects and no deaths were reported in either study2,3

Interactive PDF View Paediatric Patient Profiles

Meet our paediatric patients (aged 3 months and older) with cUTI and cIAI

DownloadLoading


† Data support the use of ZAVICEFTA in adult patients with Limited Treatment Options including in primary bacteraemia, cSSTI, BJI, meningitis, febrile neutropenia, cystic fibrosis, post-transplant patients due to KPC and OXA-48 resistance mechanisms, and MDR Pseudomonas.4-18

* ZAVICEFTA has been evaluated in paediatric patients aged 3 months to < 18 years in two Phase II single-blind, randomised, comparative clinical studies, one in patients with cIAI and one in patients with cUTI (N=128). In the cIAI trial, patients received ZAVICEFTA plus metronidazole, and in the cUTI trial, patients received ZAVICEFTA alone. The primary objective in each study was to assess safety and tolerability of ZAVICEFTA (+/- metronidazole). Secondary objectives included assessment of pharmacokinetics and efficacy; efficacy was a descriptive endpoint in both studies.1,2,3​​​​​​​

Explore more

Pathogen coverage

ZAVICEFTA has broad spectrum coverage against Gram-negative pathogens including in vitro activity against MDR P.aeruginosa, CRE, including KPC- and OXA-48 producing strains, and ESBL- and AmpC-producing bacteria1-4.


Read moreLoading

Patient Risk factors

Identifying patients at risk of MDR Gram-negative infections is vital for appropriate selection of adequate, early antimicrobial therapy to reduce the risk of fatal outcomes5.

Read moreLoading

Abbreviations:

cUTI, complicated urinary tract infection, cIAI, complicated intra-abdominal infection; HAP, hospital-acquired pneumonia; VAP, ventilator-associated pneumonia; MDR, multi-drug resistant; KPC, Klebsiella pneumoniae carbapenemase; OXA, oxacillinase; BJI, bone and joint infection;

​​​​​​​Prescribing information

Click here for Zavicefta® (ceftazidime and avibactam) Prescribing Information

Click here for Meronem® (meropenem trihydrate) Prescribing Information

Click here for Tazocin® (piperacillin sodium, tazobactam sodium) Prescribing Information

Click here for Tygacil® (tigecycline) Prescribing Information for Great Britain

Click here for Tygacil® (tigecycline) Prescribing Information Northern Ireland

Click here for Zyvox® (linezolid) Prescribing Information

Click here for Amikacin (amikacin sulfate) Prescribing Information

Click here for Dalacin® (clindamycin hydrochloride) Prescribing Information

References

ZAVICEFTA. Summary of Product Characteristics; Bradley JS, et al. Pediatr Infect Dis J 2019;38:816-24;Bradley JS, et al. Pediatr Infect Dis J 2019;38:920-8;Sousa A, et al. J Antimicrob Chemother 2018;73:3170–5.Temkin E, et al. Antimicrob Agents Chemother 2017;61:e01964-16.Shields K, et al. Antimicrob Agents Chemother 2017;61:e00883-17.Tumbarello M, et al. Clin Infect Dis 2019;68:355–64.Tumbarello M, et al. Clin Infect Dis 2021;ciab176.Tsolaki V, et al. Antimicrob Agents Chemother 2020;64:e02320-19.Rathish B, et al. Cureus 2021;13:e13081.Jabbour J-F, et al. Curr Opin Infect Dis 2020;33:146–54.Chen W, et al. Ann Transl Med 2020;8:39.Atkin SD, et al. Infect Drug Resist 2018;11:1499–510.Aguado JM, et al. Transplant Rev (Orlando) 2018;32:36–57.Soriano A, et al. Infect Dis Ther 2021;1–46.Castón JJ, et al. Int J Infect Dis 2017;59:118–23. van Duin D, et al. Clin Infect Dis 2018;66:163–71.Mazuski JE, et al. Infect Dis Ther 2021;1–16.
PP-ZVA-GBR-1800. June 2023
Learn more about ZAVICEFTA’s Phase III clinical trials in adult patients with cUTI, cIAI and HAP/VAP. Learn more about efficacy LoadingWhy we need a new approch: challenging the way we treat MDR Gram-negative infections

Listen to speakers Professor Louis Grandjean and Dr James Hatcher discuss this topic  at BSAC Spring 2023

Access results of ZAVICEFTA Phase III clinical trials in adult patients with cUTI, CIAI, or HAP/VAP

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

PfizerPro Account

To access further materials, resources and receive communication about medicines and vaccines promoted by Pfizer.

Sign In or RegisterAccountSign Out

This site is intended only for healthcare professionals resident in the United Kingdom. If you are a member of the public wishing to access information on a specific medicine, please visit www.medicines.org.uk/emc

 

This website is brought to you by Pfizer Limited, a company registered in England 

and Wales under No. 526209 with its registered office at Ramsgate Road, Sandwich, Kent, CT13 9NJ

 

Copyright © 2023 Pfizer Limited. All rights reserved.

 

VAT registration number GB201048427

PP-UNP-GBR-7284. November 2023
For UK Healthcare Professionals*

These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.

I confirm that I am a healthcare professional* resident in the United Kingdom.

If you select 'No', you will be redirected to Pfizer.co.uk where you will be able to access reference information on Pfizer's prescription medicines.

*The ABPI Code definition for healthcare professional is members of the medical, dental, pharmacy and nursing professionals and any other persons who in the course of their professional activities may administer, prescribe, purchase, recommend or supply a medicine.

PP-PFE-GBR-3863. November 2021

YesNo
You are now leaving PfizerPro​​​​​

​​​​​​​You are now leaving www.pfizerpro.co.uk. Links to external websites are provided as a resource to the viewer. This website is neither owned or controlled by Pfizer Ltd. 

Pfizer accepts no responsibility for the content or services of the linked site.​​​​​​​​​​​​​​

​​​​​​​PP-PFE-GBR-3858. November 2021​​​​​​​
​​​​​​​
You are now leaving PfizerPro
​​​​​​​
​​​​​​​You are now leaving www.pfizerpro.co.uk. Links to external websites are provided as a resource to the viewer. This website is neither owned nor controlled by Pfizer Ltd. 

Pfizer accepts no responsibility for the content or services of the linked site other than the information or other materials relating to ​​​​​Pfizer medicines or 
business which it has provided or reviewed.

PP-PFE-GBR-3859. November 2021
​​​​​​​