Information on how to access prescribing information and adverse event reporting can be found at the bottom of the page.
For patients requiring treatment of infections due to resistant, aerobic Gram-negative bacteria
ZAVICEFTA®: A combination of ceftazidime and avibactam1
Avibactam is a novel β-lactamase inhibitor combined with ceftazidime, a cephalosporin with established clinical experience2
ZAVICEFTA: Potent inhibitory activity against difficult-to-treat infections due to aerobic Gram-negative bacteria1,2
Avibactam inhibits both Ambler class A and class C β-lactamases and some class D enzymes, including1*:
• ESBLs
• KPCs
• OXA-48 carbapenemases
• AmpC enzymes
** This is an optional area where footnotes can live.
*Avibactam does not inhibit class B enzymes (metallo-β-lactamases) and is not able to inhibit many class D enzymes1.
ZAVICEFTA is effective against infections with Enterobacteriaceae and P. aeruginosa with EUCAST minimum inhibitory concentrations as follows1:
Organisms |
Susceptible |
Resistant |
|---|---|---|
Enterobacteriaceae |
≤ 8 mg/L |
> 8 mg/L |
P. aeruginosa |
≤ 8 mg/L |
> 8 mg/L |
Pathogen coverage
ZAVICEFTA has broad spectrum coverage against Gram-negative pathogens including in vitro activity against MDR P.aeruginosa, CRE, including KPC- and OXA-48 producing strains, and ESBL- and AmpC-producing bacteria1-4.
Read more
Patient Risk factors
Identifying patients at risk of MDR Gram-negative infections is vital for appropriate selection of adequate, early antimicrobial therapy to reduce the risk of fatal outcomes5.
Read more
Abbreviations:
cUTI, complicated urinary tract infection, cIAI, complicated intra-abdominal infection; HAP, hospital-acquired pneumonia; VAP, ventilator-associated pneumonia; MDR, multi-drug resistant; BL/BLI, β-lactam/β-lactamase inhibitors; CRE, carbapenem-resistant Enterobacteriaceae; KPC, Klebsiella pneumoniae carbapenemase; MBL, metallo-β-lactamase; OXA, oxacillinase; ESBL, extended-spectrum β-lactamase; CrCl, creatinine clearance; ELF, epithelial lining fluid; AMR, Antimicrobial Resistance; MIC, minimum inhibitory concentration; EUCAST, European Committee on Antimicrobial Susceptibility Testing;
Prescribing information
- ZAVICEFTA. Summary of Product Characteristics
- Liscio JL, et al. Int J Antimicrob Agents 2015;46:266–71
- Nicolau DP, et al. J Antimicrob Chemother 2015;70:2862–9
- Mazuski JE, et al. Surg Infect 2017;18:1–76
- Bonine NG, et al. Am J Med Sci 2019;357:102–10
Learn more about ZAVICEFTA’s Phase III clinical trials in adult patients with cUTI, cIAI and HAP/VAP.
Learn more about efficacy
Learn more about the tolerability data of ZAVICEFTA from four Phase III clinical trials.
View safety profile
ZAVICEFTA’ s indications and its role in clinical practice
Dr Matthew Dryden, Consultant Microbiologist at Hampshire Hospitals presents ZAVICEFTA’ s indications and its role in clinical practice.
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