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Adverse event reporting can be found at the bottom of the page

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AboutAboutPathogen CoveragePatient Risk FactorsAntimicrobial Subscription Model PilotDosingDosingDosingPreparation GuideShelf Life and StorageEfficacy & SafetyEfficacy & SafetyMechanism of ActionREPROVE Phase III trial(HAP/VAP)RECLAIM Phase III trial(cIAI)RECAPTURE Phase III trial(cUTI)REPRISE Phase III trial(cIAI and cUTI)Safety and TolerabilityEfficacy and Safety Data for Paediatric PatientsSupport & ResourcesSupport & ResourcesAMS ResourcesSepsisWebinars (Live and On-demand)KOL Videos - ZaviceftaKOL Videos - Gram-negativeKOL Videos - Clinical experienceVideosMaterials

Information on how to access prescribing information and adverse event reporting can be found towards the bottom of the page.

For patients requiring treatment of infections due to resistant, aerobic Gram-negative bacteriaZAVICEFTA®: A combination of ceftazidime and avibactam1

Avibactam is a β-lactamase inhibitor combined with ceftazidime, a cephalosporin with established clinical experience2

ZAVICEFTA: Potent inhibitory activity against difficult-to-treat infections due to aerobic Gram-negative bacteria1,2

Avibactam inhibits both Ambler class A and class C β-lactamases and some class D enzymes, including1*:
•    ESBLs
•    KPCs
•    OXA-48 carbapenemases
•    AmpC enzymes

*Avibactam does not inhibit class B enzyme​​​​​​​s (metallo-β-lactamases) and is not able to inhibit many class D enzymes1.

ZAVICEFTA is effective against infections with Enterobacteriaceae and P. aeruginosa with EUCAST minimum inhibitory concentrations as follows1:

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Organisms Susceptible Resistant
Enterobacteriaceae ≤ 8 mg/L > 8 mg/L
P. aeruginosa ≤ 8 mg/L > 8 mg/L
Pathogen coverage

ZAVICEFTA has broad spectrum coverage against Gram-negative pathogens including in vitro activity against MDR P.aeruginosa, CRE, including KPC- and OXA-48 producing strains, and ESBL- and AmpC-producing bacteria1-4.

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Patient Risk factors

Identifying patients at risk of MDR Gram-negative infections is vital for appropriate selection of adequate, early antimicrobial therapy to reduce the risk of fatal outcomes5.

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Abbreviations:​​​​​​​

​​​​​​​cUTI, complicated urinary tract infection, cIAI, complicated intra-abdominal infection; HAP, hospital-acquired pneumonia; VAP, ventilator-associated pneumonia; MDR, multi-drug resistant; BL/BLI, β-lactam/β-lactamase inhibitors; CRE, carbapenem-resistant Enterobacteriaceae; KPC, Klebsiella pneumoniae carbapenemase; MBL, metallo-β-lactamase; OXA, oxacillinase; ESBL, extended-spectrum β-lactamase; CrCl, creatinine clearance; ELF, epithelial lining fluid; AMR, Antimicrobial Resistance; MIC, minimum inhibitory concentration; EUCAST, European Committee on Antimicrobial Susceptibility Testing;

Prescribing information

Click here for Zavicefta (ceftazidime and avibactam) Prescribing Information

References

ZAVICEFTA. Summary of Product CharacteristicsLiscio JL, et al. Int J Antimicrob Agents 2015;46:266–71Nicolau DP, et al. J Antimicrob Chemother 2015;70:2862–9Mazuski JE, et al. Surg Infect 2017;18:1–76Bonine NG, et al. Am J Med Sci 2019;357:102–10
PP-ZVA-GBR-1723. February 2023
Learn more about ZAVICEFTA’s Phase III clinical trials in adult patients with cUTI, cIAI and HAP/VAP. Learn more about efficacy Loading Learn more about the tolerability data of ZAVICEFTA from four Phase III clinical trials. View tolerability profile LoadingZAVICEFTA’ s indications and its role in clinical practice

Dr Matthew Dryden, Consultant Microbiologist at Hampshire Hospitals presents ZAVICEFTA’ s indications and its role in clinical practice. ​​

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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