Information on how to access prescribing information and adverse event reporting can be found at the bottom of the page.
Avibactam is a novel β-lactamase inhibitor combined with ceftazidime, a cephalosporin with established clinical experience2
Avibactam inhibits both Ambler class A and class C β-lactamases and some class D enzymes, including1*:
• ESBLs
• KPCs
• OXA-48 carbapenemases
• AmpC enzymes
** This is an optional area where footnotes can live.
*Avibactam does not inhibit class B enzymes (metallo-β-lactamases) and is not able to inhibit many class D enzymes1.
ZAVICEFTA is effective against infections with Enterobacteriaceae and P. aeruginosa with EUCAST minimum inhibitory concentrations as follows1:
Organisms |
Susceptible |
Resistant |
---|---|---|
Enterobacteriaceae |
≤ 8 mg/L |
> 8 mg/L |
P. aeruginosa |
≤ 8 mg/L |
> 8 mg/L |
ZAVICEFTA has broad spectrum coverage against Gram-negative pathogens including in vitro activity against MDR P.aeruginosa, CRE, including KPC- and OXA-48 producing strains, and ESBL- and AmpC-producing bacteria1-4.
Read more
Identifying patients at risk of MDR Gram-negative infections is vital for appropriate selection of adequate, early antimicrobial therapy to reduce the risk of fatal outcomes5.
Read more
Abbreviations:
cUTI, complicated urinary tract infection, cIAI, complicated intra-abdominal infection; HAP, hospital-acquired pneumonia; VAP, ventilator-associated pneumonia; MDR, multi-drug resistant; BL/BLI, β-lactam/β-lactamase inhibitors; CRE, carbapenem-resistant Enterobacteriaceae; KPC, Klebsiella pneumoniae carbapenemase; MBL, metallo-β-lactamase; OXA, oxacillinase; ESBL, extended-spectrum β-lactamase; CrCl, creatinine clearance; ELF, epithelial lining fluid; AMR, Antimicrobial Resistance; MIC, minimum inhibitory concentration; EUCAST, European Committee on Antimicrobial Susceptibility Testing;
Prescribing information
Learn more about efficacy
View safety profile
Dr Matthew Dryden, Consultant Microbiologist at Hampshire Hospitals presents ZAVICEFTA’ s indications and its role in clinical practice.
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