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Patients with favourable clinical response at TOC (%)§
Baseline pathogens: Predominantly E. coli and K. pneumoniae including some ceftazidime-resistant strains.
333 hospitalised adults with a cUTI or cIAI
View trial results
879 hospitalised adults with HAP and VAP
View trial results
1066 hospitalised adults with cIAI
View trial results
§Non-inferiority was concluded if the lower limit of the 95% CI was greater than –12.5%.
†The mMITT population comprised all randomised patients with minimum disease criteria and eligible baseline pathogen(s).
*Consideration should be given to official guidance on the appropriate use of antibacterial agents
Abbreviations:
AE, adverse event; CE, clinically evaluable; CI, confidence interval; cMITT, clinically modified intention-to-treat; HAP, hospital-acquired pneumonia; K. pneumoniae, Klebsiella pneumoniae; P. aeruginosa, Pseudomonas aeruginosa; TOC, test of cure; VAP, ventilator-associated pneumonia; cIAI, complicated intra-abdominal infection; E.coli, Escherichia coli; MITT, modified intention-to-treat; cUTI, complicated urinary tract infection.
Prescribing information
Zavicefta® (ceftazidime and avibactam)
Great Britain
Zavicefta®(ceftazidime and avibactam) 2g/0.5 g Powder for Concentrate for Solution for Infusion
Northern Ireland
Zavicefta®(ceftazidime and avibactam) 2g/0.5 g Powder for Concentrate for Solution for Infusion
Meronem® (meropenem trihydrate)
Meronem® (meropenem triydrate) IV 1g
Meronem® (meropenem triydrate) IV 500mg
Gentamicin (gentamicin sulfate) 40 mg/ml Injection
Legal Category: Prescription Only Medicine (POM)
NHS Price: 5 vial £20.00
Click here for the Summary of Product Characteristics
View tolerability profile
Listen to Paschalis Vergidis, Infectious Diseases Consultant at Manchester University NHS Foundation Trust, sharing his view on the challenges of MDR Gram-negative infections. Learn about his clinical practice experience in a renal transplant patient and the role of ceftazidime-avibactam in patients with cUTI.
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