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Information on how to access prescribing information and adverse event reporting can be found at the bottom of the page.

ZAVICEFTA® is indicated for the treatment of complicated urinary tract infections, including pyelonephritis1*

ZAVICEFTA is as effective as a carbapenem in patients with cUTI caused by Gram-negative pathogens2

RECAPTURE Phase III trial: 1033 hospitalised adults with cUTI

Patients with favourable clinical response at TOC (%)§

Baseline pathogens: Predominantly E. coli and K. pneumoniae including some ceftazidime-resistant strains.

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REPRISE Phase III trial:

333 hospitalised adults with a cUTI or cIA​​​​​​​I

View trial results

REPROVE Phase III trial:

879 hospitalised adults with HAP and VAP

View trial results

RECLAIM Phase III trial:

1066 hospitalised adults with cIAI​​​​​​​

View trial results


§Non-inferiority was concluded if the lower limit of the 95% CI was greater than –12.5%.
The mMITT population comprised all randomised patients with minimum disease criteria and eligible baseline pathogen(s).
*Consideration should be given to official guidance on the appropriate use of antibacterial agents

Abbreviations:

AE, adverse event; CE, clinically evaluable; CI, confidence interval; cMITT, clinically modified intention-to-treat; HAP, hospital-acquired pneumonia; K. pneumoniae, Klebsiella pneumoniae; P. aeruginosa, Pseudomonas aeruginosa; TOC, test of cure; VAP, ventilator-associated pneumonia; cIAI, complicated intra-abdominal infection; E.coli, Escherichia coli; MITT, modified intention-to-treat; cUTI, complicated urinary tract infection. ​​​​​​​

Prescribing information

Zavicefta (ceftazidime and avibactam) 2g/0.5 g Powder for Concentrate for Solution for Infusion

Meronem® (meropenem triydrate) IV 1g

Meronem® (meropenem triydrate) IV 500mg​​​​​​​

Gentamicin (gentamicin sulfate) 40 mg/ml Injection
Legal Category: Prescription Only Medicine (POM)
NHS Price: 5 vial £20.00 
Click here for the Summary of Product Characteristics

References:
  1. ZAVICEFTA. Summary of Product Characteristics;
  2. Wagenlehner FM, et al. Clin Infect Dis 2016;63:754–62
PP-ZVA-GBR-0838. June 2021

Learn more about the tolerability data of ZAVICEFTA from four Phase III clinical trials.

View safety profile

Paschalis Vergidis

Listen to Paschalis Vergidis, Infectious Diseases Consultant at Manchester University NHS Foundation Trust, sharing his view on the challenges of MDR Gram-negative infections. Learn about his clinical practice experience in a renal transplant patient and the role of ceftazidime-avibactam in patients with  cUTI.

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PP-PFE-GBR-2688. December 2020

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