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Adverse event reporting can be found at the bottom of the page
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Information on how to access prescribing information and adverse event reporting can be found towards the bottom of the page.
Patients with favourable clinical response at TOC (%)§
Baseline pathogens: E. coli, K. pneumoniae and P. aeruginosa including some ceftazidime-resistant strains. 417 patients (40%) had polymicrobial infection at baseline.
333 hospitalised adults with a cUTI or cIAI
1033 hospitalised adults with cUTI.
879 hospitalised adults with HAP and VAP
§Non-inferiority was considered met if the lower limit of the 95% CI for between-group difference was greater than the prespecified non-inferiority margin of –12.5%.
†Patients in the MITT population are defined as patients who received study drug and met the clinical disease criteria.
*Consideration should be given to official guidance on the appropriate use of antibacterial agents
Abbreviations:
AE, adverse event; CE, clinically evaluable; CI, confidence interval; cMITT, clinically modified intention-to-treat; HAP, hospital-acquired pneumonia; K. pneumoniae, Klebsiella pneumoniae; P. aeruginosa, Pseudomonas aeruginosa; TOC, test of cure; VAP, ventilator-associated pneumonia; cIAI, complicated intra-abdominal infection; E.coli, Escherichia coli; MITT, modified intention-to-treat; cUTI, complicated urinary tract infection.
Prescribing information
Click here for ZAVICEFTA® (ceftazidime avibactam) prescribing information
Click here for MERONEM® (meropenem trihydrate) prescribing information
Click here for TYGACIL® (tigecycline) prescribing information in Great Britain
Click here for TYGACIL® (tigecycline) prescribing information in Northern Ireland
Professor Jonathan Edgeworth
Professor Jonathan Edgeworth, Consultant Microbiologist from Guy's and St. Thomas' NHS Trust talks about the benefit of new antibiotics to treat CRE. He also presents his experience using ceftazidime-avibactam in a patient in intensive care with MDR Klebsiella.
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Adverse events should also be reported to Pfizer Medical Information on 01304 616161
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PP-PFE-GBR-3863. November 2021