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ZAVICEFTA® is indicated for the treatment of complicated intra-abdominal infections1*

ZAVICEFTA is as effective as a carbapenem when combined with metronidazole in patients with cIAI caused by Gram-negative pathogens2

RECLAIM Phase III trial: 1066 hospitalised adults with cIAI

Patients with favourable clinical response at TOC (%)§

Baseline pathogens: E. coliK. pneumoniae and P. aeruginosa including some ceftazidime-resistant strains. 417 patients (40%) had polymicrobial infection at baseline.

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REPRISE Phase III trial:

333 hospitalised adults with a cUTI or cIAI

View trial results

RECAPTURE Phase III trial:

1033 hospitalised adults with cUTI.

View trial results

REPROVE Phase III trial:

879 hospitalised adults with HAP and VAP

View trial results


§Non-inferiority was considered met if the lower limit of the 95% CI for between-group difference was greater than the prespecified non-inferiority margin of –12.5%.
†Patients in the MITT population are defined as patients who received study drug and met the clinical disease criteria.
*Consideration should be given to official guidance on the appropriate use of antibacterial agents

Abbreviations:

AE, adverse event; CE, clinically evaluable; CI, confidence interval; cMITT, clinically modified intention-to-treat; HAP, hospital-acquired pneumonia; K. pneumoniae, Klebsiella pneumoniae; P. aeruginosa, Pseudomonas aeruginosa; TOC, test of cure; VAP, ventilator-associated pneumonia; cIAI, complicated intra-abdominal infection; E.coli, Escherichia coli; MITT, modified intention-to-treat; cUTI, complicated urinary tract infection.

References:
  1. ZAVICEFTA. Summary of Product Characteristics;
  2. Mazuski JE, et al. Clin Infect Dis 2016;62:1380–9.
PP-ZVA-GBR-0838. June 2021

Learn more about the tolerability data of ZAVICEFTA from four Phase III clinical trials.

View safety profile

Professor Jonathan Edgeworth

Professor Jonathan Edgeworth, Consultant Microbiologist from Guy's and St. Thomas' NHS Trust talks about the benefit of new antibiotics to treat CRE. He also presents his experience using ceftazidime-avibactam in a patient in intensive care with MDR Klebsiella.

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PP-PFE-GBR-2688. December 2020

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