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Information on how to access prescribing information and adverse event reporting can be found at the bottom of the page.

ZAVICEFTA® is indicated for the treatment of hospital-acquired pneumonia (HAP), including ventilator associated pneumonia (VAP)1*

ZAVICEFTA is as effective as a carbapenem in hospitalised patients with aerobic Gram-negative HAP, including VAP2,3

REPROVE Phase III trial: 879 hospitalised adults with hospital-acquired pneumonia and ventilator-associated pneumonia.​​​​​​​

Patients with favourable clinical response at TOC (%)§​​​​​​​

Baseline pathogens: predominantly K. pneumoniae and P. aeruginosa including some ceftazidime-resistant strains. 100 patients (28%) had > 1 ceftazidime-resistant isolate.​​​​​​​

REPRISE Phase III trial:

333 hospitalised adults with a cUTI or cIAI

View trial results

RECAPTURE Phase III trial:

1033 hospitalised adults with cUTI.

View trial results

RECLAIM Phase III trial:

1066 hospitalised adults with cIAI

View trial results

§Non-inferiority was concluded if the lower limit of the 95% CI was greater than –12.5%.2
cMITT population comprised patients with minimum disease criteria but excluded patients with only non-target pathogens.2 
​​​​​​​‡The clinically evaluable population comprised patients in the cMITT population who received an adequate course of treatment and had an assessable clinical outcome within the assessment window, no protocol deviations that could affect the assessment of efficacy, and no unacceptable previous or concomitant antibiotics.2
*Consideration should be given to official guidance on the appropriate use of antibacterial agents​​​​​​​


​​​​​​​AE, adverse event; CE, clinically evaluable; CI, confidence interval; cMITT, clinically modified intention-to-treat; HAP, hospital-acquired pneumonia; K. pneumoniae, Klebsiella pneumoniae; P. aeruginosa, Pseudomonas aeruginosa; TOC, test of cure; VAP, ventilator-associated pneumonia; cIAI, complicated intra-abdominal infection; E.coli, Escherichia coli; MITT, modified intention-to-treat; cUTI, complicated urinary tract infection.

  1. ZAVICEFTA. Summary of Product Characteristics;
  2. Torres A, et al. Lancet Infect Dis 2018;18:285–95
  3. Torres A, et al. Open Forum Infect Dis 2019;6:ofz149 ​​​​​​​
PP-ZVA-GBR-1403 January 2022

1033 hospitalised adults with cUTI.

Learn more about the tolerability data of ZAVICEFTA from four Phase III clinical trials.

View safety profile

Professor Antoni Torres

Professor of Pulmonology and Respiratory Critical Care Medicine at University of Barcelona, Spain, talks about hospital-acquired pneumonia and ventilator-associated pneumonia, as well as the REPROVE study, a Phase III randomised clinical trial comparing ceftazidime-avibactam to meropenem.

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PP-PFE-GBR-3863. November 2021



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