ZAVICEFTA® (ceftazidime-avibactam): A safety and tolerability profile consistent with both cephalosporins and carbapenems^1-4

Special warnings and precautions for use⁵

Hypersensitivity reactions⁵

Serious and occasionally fatal hypersensitivity reactions are possible. In case of hypersensitivity reactions, treatment with ZAVICEFTA must be discontinued immediately and adequate emergency measures must be initiated. 

Before beginning treatment, it should be established whether the patient has a history of hypersensitivity reactions to ceftazidime, to other cephalosporins or to any other type of β-lactam antibacterial agent. Caution should be used if ceftazidime/ avibactam is given to patients with a history of non-severe hypersensitivity to penicillins, monobactams or carbapenems. 

Clostridium difficile-associated diarrhoea⁵

Clostridium difficile-associated diarrhoea has been reported with ceftazidime/ avibactam and can range in severity from mild to life-threatening. 

This diagnosis should be considered in patients who present with diarrhoea during or subsequent to administration of ZAVICEFTA. 

Discontinuation of therapy with ZAVICEFTA and the administration of specific treatment for Clostridium difficile should be considered. Medicinal products that inhibit peristalsis should not be given.