Information on how to access prescribing information and adverse event reporting can be found at the bottom of the page.
Adverse Events
Special Warnings and Precautions for Use
Drug-drug interactions
Serious and occasionally fatal hypersensitivity reactions are possible. In case of hypersensitivity reactions, treatment with ZAVICEFTA must be discontinued immediately and adequate emergency measures must be initiated.
Before beginning treatment, it should be established whether the patient has a history of hypersensitivity reactions to ceftazidime, to other cephalosporins or to any other type of β-lactam antibacterial agent. Caution should be used if ceftazidime/ avibactam is given to patients with a history of non-severe hypersensitivity to penicillins, monobactams or carbapenems.
Clostridium difficile-associated diarrhoea has been reported with ceftazidime/ avibactam and can range in severity from mild to life-threatening.
This diagnosis should be considered in patients who present with diarrhoea during or subsequent to administration of ZAVICEFTA.
Discontinuation of therapy with ZAVICEFTA and the administration of specific treatment for Clostridium difficile should be considered. Medicinal products that inhibit peristalsis should not be given.
Patient Risk Factors
Pathogen Coverage
AMS Resources
Prescribing information
Zavicefta (ceftazidime and avibactam) 2g/0.5 g Powder for Concentrate for Solution for Infusion
Meronem® (meropenem triydrate) IV 1g
Meronem® (meropenem triydrate) IV 500mg
Tazocin® (piperacillin sodium, tazobactam sodium) 2g/0.25g Powder for Solution for Infusion
Tazocin® (piperacillin sodium, tazobactam sodium) 4g/0.5g Powder for Solution for Infusion
Amikacin (amikacin sulfate) 500mg/2ml solution for injection
Legal Category: Prescription Only Medicine (POM)
NHS Price: 5 vial pack £60.00
Click here for the Summary of Product Characteristics
Tobramycin (tobramycin)
Tobramycin 240mg/6ml solution for injection
Legal Category: Prescription Only Medicine (POM)
Basic NHS Cost: 1 vial £19.20
Click here for the Summary of Product Characteristics
Tobramycin 80mg/2ml solution for injection
Legal Category: Prescription Only Medicine (POM)
Basic NHS Cost: 5 vial £20.80
Click here for the Summary of Product Characteristics
Gentamicin (gentamicin sulfate) 40 mg/ml Injection
Legal Category: Prescription Only Medicine (POM)
NHS Price: 5 vial £20.00
Click here for the Summary of Product Characteristics
Ciprofloxacin (ciprofloxacin lactate) 2 mg/ml Solution for Infusion
Legal Category: Prescription Only Medicine (POM)
NHS Price: 10 bag £200.00
Click here for the Summary of Product Characteristics
REPROVE Phase III trial (HAP/VAP)
RECLAIM Phase III trial (cIAI)
RECAPTURE Phase III trial (cUTI)
REPRISE Phase III trial (cIAI and cUTI)
Infectious Disease Physician at Hospital Clinic in Barcelona, Spain, summarises key ZAVICEFTA data against other β-lactam/β-lactamase inhibitor combinations. He discusses ZAVICEFTA’s in vitro activity and broad-spectrum coverage against MDR P. aeruginosa and Enterobacteriaceae (including Klebsiella pneumoniae, Escherichia coli and ESBL-producing strains).
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