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ZAVICEFTA® (ceftazidime-avibactam): Broad-spectrum Gram-negative coverage with consistent dosing across indications1–5

Dosing Guide Preparation Guide Shelf life and Storage
Adult Patients Paediatric Patients

When treating for cIAI, cUTI, HAP/VAP or LTO to be used in combination with an antibacterial agent active against Gram-positive pathogens when these are known or suspected to be contributing to the infectious process. 
When treating for cIAI or LTO, to be used in combination with metronidazole when anaerobic pathogens are known or suspected to be contributing to the infectious process.

Table 3 footnotes:
*  CrCL estimated using the Schwartz bedside formula.
¶ The total treatment duration shown may include intravenous ZAVICEFTA followed by appropriate oral therapy.
ǁ There is very limited experience with the use of ZAVICEFTA for more than 14 days.
**There is limited experience with the use of ZAVICEFTA in paediatric patients 3 months to < 6 month.​​​​​​​
​​​​

​​​​​​​Table 4. Great Britain​​​​​ recommended dose for paediatric patients1 with estimated CrCL* ≤ 50 mL/min/1.73 m2

​​​​​​​Table 4. Northern Ireland recommended dose for paediatric patients5 with estimated CrCL* ≤ 50 mL/min/1.73 m2

Table 4 footnotes:
*CrCL estimated using the Schwartz beside formula
† Dose recommendations are based on pharmacokinetic modelling. Ceftazidime/avibactam is a combination product in a fixed 4:1 ratio and dosage recommendations are based on the ceftazidime component only

**Ceftazidime and avibactam are removed by haemodialysis. Dosing of ZAVICEFTA on haemodialysis days should occur after completion of haemodialysis

Table 5. Recommended dose for paediatric patients ≥ 3 months and < 2 years of age1,5 with estimated CrCL* ≤ 50 mL/min/1.73 m2​​​​​​​

Table 5 footnotes:
​​​​​​​*CrCL estimated using the Schwartz bedside formula
†Dose recommendations are based on pharmacokinetic modelling. Ceftazidime/avibactam is a combination product in a fixed 4:1 ratio and dosage recommendations are based on the ceftazidime component only


There is insufficient information to recommend a dosage regimen for paediatric patients < 2 years of age that have a CrCL < 16 mL/min/1.73m2


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​​​​​​​​​​​Explore more​​​​​​​​​​​​​​​​​​​​​

Paediatric Tolerability and Efficacy Data

ZAVICEFTA® (ceftazidime-avibactam): For the treatment of adult and paediatric patients aged 3 months and older at high risk of MDR Gram-negative infections1

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Access results of ZAVICEFTA Phase III clinical trials in adult patients with cUTI, cIAI or HAP/VAP

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Abbreviations

cIAI, complicated intra-abdominal infection; CrCL, creatinine clearance; cUTI, complicated urinary tract infection; ESRD, end stage renal disease; HAP, hospital-acquired pneumonia; LTO, limited treatment options; VAP, ventilator-associated pneumonia; AMR, Antimicrobial Resistance; PK/PD, pharmacokinetics/pharmacodynamics.

References
  1. ZAVICEFTA. Summary of Product Characteristics (Great Britain)
  2. Liscio JL, et al. Int J Antimicrob Agents 2015;46:266–7
  3. Nicolau DP, et al. J Antimicrob Chemother 2015;70:2862–9
  4. ​​​​​​​Mazuski JE, et al. Surg Infect 2017;18:1–76
  5. ZAVICEFTA. Summary of Product Characteristics (Northern Ireland)
PP-ZVA-GBR-1546. May 2022

Learn more about the tolerability data of ZAVICEFTA from four Phase III clinical trials.

View tolerability profile

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Ask Zavibot a Question
PK/PD attributes of ceftazidime–avibactam in patients

Federico Pea, Professor of Pharmacology at the University of Bologna, Italy, presents the 'PK/PD attributes of ceftazidime–avibactam in patients'. 

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PP-PFE-GBR-3863. November 2021

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