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ZAVICEFTA® (ceftazidime-avibactam): Broad-spectrum Gram-negative coverage with consistent dosing across indications1–4

Dosing Guide

Preparation Guide

Shelf life and Storage

Shelf life and storage1

Dry powder vial

  • Store in the original package in order to protect from light
  • The vial has a shelf life of three years

After reconstitution

  • Parenteral medicinal products should be inspected visually for particulate matter prior to administration
  • The compatibility of ZAVICEFTA with other medicines has not been established 
  • ZAVICEFTA should not be mixed with or physically added to solutions containing other medicinal products
  • Each vial is for single use only
  • The reconstituted vial should be used immediately

After dilution

  • The SmpC for Great Britain states that chemical and physical in-use stability has been demonstrated for the diluted infusion for up to 24 hours at 2–8°C, followed by up to 12 hours at room temperature at not more than 25°C1(Please note: the SmPC for Northern Ireland states that the dilution should be stored up to 12 hours at 2–8°C, followed by up to 4 hours at room temperature at not more than 25°C)5
  • From a microbiological point of view, the diluted infusion should be used immediately unless reconstitution/dilution has taken place in controlled and validated aseptic conditions

Access results of ZAVICEFTA Phase III clinical trials in adult patients with cUTI, cIAI or HAP/VAP

Access case studies and videos


Abbreviations

cIAI, complicated intra-abdominal infection; cUTI, complicated urinary tract infection; HAP, hospital-acquired pneumonia; VAP, ventilator-associated pneumonia; AMR, Antimicrobial Resistance.

Prescribing information
​​​​​​​Zavicefta® (ceftazidime and avibactam)

References
  1. ZAVICEFTA. Summary of Product Characteristics (Great Britain)
  2. Liscio JL, et al. Int J Antimicrob Agents 2015;46:266–7
  3. Nicolau DP, et al. J Antimicrob Chemother 2015;70:2862–9
  4. Mazuski JE, et al. Surg Infect 2017;18:1–76
  5.  ZAVICEFTA. Summary of Product Characteristics (Northern Ireland)
PP-ZVA-GBR-1546. May 2022

Learn more about the tolerability data of ZAVICEFTA from four Phase III clinical trials.

View tolerability profile

Quick Links

  • Patient Risk Factors

  • Pathogen Coverage

  • AMS Resources

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