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AboutAboutPathogen CoveragePatient Risk FactorsAntimicrobial Subscription Model PilotDosingDosingDosingPreparation GuideShelf Life and StorageEfficacy & SafetyEfficacy & SafetyMechanism of ActionREPROVE Phase III trial(HAP/VAP)RECLAIM Phase III trial(cIAI)RECAPTURE Phase III trial(cUTI)REPRISE Phase III trial(cIAI and cUTI)Safety and TolerabilityEfficacy and Safety Data for Paediatric PatientsSupport & ResourcesSupport & ResourcesAMS ResourcesSepsisWebinars (Live and On-demand)KOL Videos - ZaviceftaKOL Videos - Gram-negativeKOL Videos - Clinical experienceVideosMaterials

Information on how to access prescribing information and adverse event reporting can be found towards the bottom of the page.

Sepsis

Sepsis is a common and potentially life-threatening condition triggered by an infection leading to the body injuring its own tissues and organs.1,2 If it is not treated quickly, it can lead to tissue damage, multiple organ failure and death. It claims more lives than lung cancer and is the second biggest killer after cardiovascular disease. There are an estimated 123,000 cases of sepsis per year in England, and around 36,800 associated deaths. In many cases however, sepsis is avoidable and treatable and early identification is key to successfully treating sepsis.3

Know the symptoms of Sepsis: 4,5,6,7

  • Slurred speech
  • Extreme shivering and muscle pain
  • Passing no urine all day
  • Severe breathlessness 
  • Increased heart rate
  • Skin discolouration 

Watch this video by Dr Luke Moore, Consultant Infectious Diseases and Clinical Microbiology & Virology, Chelsea & Westminster NHS Foundation Trust to find out more:


Watch this video by Mary Millard as she shares her experience of this life-threatening condition and the impact it continues to have:

Explore more​​​​​​​

Patient Risk Factors

Identifying patients at risk of MDR Gram-negative infections is vital for appropriate selection of adequate, early antimicrobial therapy to reduce the risk of fatal outcomes5.


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Pathogen coverage

ZAVICEFTA has broad spectrum coverage against Gram-negative pathogens including in vitro activity against MDR P.aeruginosa, CRE, including KPC- and OXA-48 producing strains, and ESBL- and AmpC-producing bacteria1-4.


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Antimicrobial Stewardship

Access our resources for implementation of an Antimicrobial Stewardship Programme and learn more about Pfizer initiatives to fight AMR

 

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References: 
1. Singer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315:801-810.
2. Evans L, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021 Nov;47(11):1181-1247.
3.  NHS Health Education England, Sepsis Awareness  https://www.hee.nhs.uk/our-work/sepsis-awareness  last accessed August 2023.
4. World Sepsis Day. Sepsis. Available at: https://www.worldsepsisday.org/sepsis Last accessed August 2023.
5. Centers for Disease Control and Prevention (CDC). Protect your patients from sepsis. Available at: https://www.cdc.gov/sepsis/pdfs/hcp/HCP_fact-sheet_protect-your-patients-from-sepsis-P.pdf  Last accessed: August 2023.
6. World Health Organization (WHO). Sepsis fact sheet. Updated 26 August 2020. Available at: https://www.who.int/news-room/fact-sheets/detail/sepsis Last accessed August 2023.
7. Rudd KE, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395:200-211.

Prescribing information:

Click here for Prescribing Information for Zavicefta® (ceftazidime and avibactam)
Click here for Prescribing Information for Meronem® (meropenem trihydrate)


Tygacil® (tigecycline)
Great Britain
Tygacil® (tigecycline) 50mg powder for solution for infusion
Northern Ireland
Tygacil® (tigecycline) 50mg powder for solution for infusion

PP-ZVA-GBR-1860. August 2023.
Access case studies and videos Efficacy of Zavicefta

Find out more about the efficacy data from Phase III clinical trials 

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Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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