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Adverse event reporting can be found at the bottom of the page
Sepsis is a common and potentially life-threatening condition triggered by an infection leading to the body injuring its own tissues and organs.1,2 If it is not treated quickly, it can lead to tissue damage, multiple organ failure and death. It claims more lives than lung cancer and is the second biggest killer after cardiovascular disease. There are an estimated 123,000 cases of sepsis per year in England, and around 36,800 associated deaths. In many cases however, sepsis is avoidable and treatable and early identification is key to successfully treating sepsis.3
Know the symptoms of Sepsis: 4,5,6,7
Watch this video by Dr Luke Moore, Consultant Infectious Diseases and Clinical Microbiology & Virology, Chelsea & Westminster NHS Foundation Trust to find out more:
Watch this video by Mary Millard as she shares her experience of this life-threatening condition and the impact it continues to have:
Identifying patients at risk of MDR Gram-negative infections is vital for appropriate selection of adequate, early antimicrobial therapy to reduce the risk of fatal outcomes5.
ZAVICEFTA has broad spectrum coverage against Gram-negative pathogens including in vitro activity against MDR P.aeruginosa, CRE, including KPC- and OXA-48 producing strains, and ESBL- and AmpC-producing bacteria1-4.
Access our resources for implementation of an Antimicrobial Stewardship Programme and learn more about Pfizer initiatives to fight AMR
References:
1. Singer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315:801-810.
2. Evans L, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021 Nov;47(11):1181-1247.
3. NHS Health Education England, Sepsis Awareness https://www.hee.nhs.uk/our-work/sepsis-awareness last accessed August 2023.
4. World Sepsis Day. Sepsis. Available at: https://www.worldsepsisday.org/sepsis Last accessed August 2023.
5. Centers for Disease Control and Prevention (CDC). Protect your patients from sepsis. Available at: https://www.cdc.gov/sepsis/pdfs/hcp/HCP_fact-sheet_protect-your-patients-from-sepsis-P.pdf Last accessed: August 2023.
6. World Health Organization (WHO). Sepsis fact sheet. Updated 26 August 2020. Available at: https://www.who.int/news-room/fact-sheets/detail/sepsis Last accessed August 2023.
7. Rudd KE, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020;395:200-211.
Prescribing information:
Click here for Prescribing Information for Zavicefta® (ceftazidime and avibactam)
Click here for Prescribing Information for Meronem® (meropenem trihydrate)
Tygacil® (tigecycline)
Great Britain
Tygacil® (tigecycline) 50mg powder for solution for infusion
Northern Ireland
Tygacil® (tigecycline) 50mg powder for solution for infusion
Find out more about the efficacy data from Phase III clinical trials
Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search
for MHRA Yellow Card in Google Play or Apple App Store
Adverse events should also be reported to Pfizer Medical Information on 01304 616161
To access further materials, resources and receive communication about medicines and vaccines promoted by Pfizer.
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PP-PFE-GBR-3863. November 2021