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Zinforo® is a fifth-generation cephalosporin with coverage against key pathogens in cSSTI and CAP1,2

Increased range of activity relative to third-generation compounds2

Rapid bactericidal in vitro activity against resistant Gram-positive pathogens, including MRSA in cSSTI and penicillin-resistant Streptococcus pneumoniae in CAPˠ1–4

Clinical efficacy has been demonstrated against the following pathogens:†1

Gram-negative

Gram-positive

Klebsiella pneumoniae

Staphylococcus aureus (MSSA only)

Haemophilius influenzae

Streptococcus pneumoniaeˠ

Haemophilius parainfluenzae

Escherichia coli

Gram-negative

Gram-positive

Escherichia coli

Staphylococcus aureus (MRSA & MSSA)

Klebsiella pneumoniae

Streptococcus pyogenes

Klebsiella oxytoca

Streptococcus agalactiae

Morganella morganii

Streptococcus anginosus group

Streptococcus dysgalactiae

Staphylococcus aureus and Streptococcus pneumoniae are key pathogens in cSSTI and CAP in paediatric patientsˠ5-8,11,12,14-16

S.aureus, including methicillin-resistant strains, is a major cause of cSSTI in children and adults5,6

S. pneumoniae is the most common pathogen associated with CAP in childhood.ˠ7-10 S.aureus has also emerged as a key causative pathogen.7-9

Infections caused by these pathogens are associated with increased rates of hospitalisation, complications (e.g. empyema) and mortality5,6,8,11-13

Explore more

Investigate the outcomes of the Zinforo Phase III clinical trials in adult patients with CAP and cSSTI ​​​​​​​

Efficacy
†Zinforo is not active against Pseudomonas aeruginosa. Like other cephalosporins, Zinforo is not active against ESBL-producing strains. In vitro activity does not always correlate with clinical efficacy.1
ˠThe available clinical data cannot substantiate efficacy against penicillin non-susceptible strains of S.pneumoniae.1
‡There is no experience with Zinforo in the treatment of CAP in the following patient groups: the immunocompromised, patients with severe sepsis/septic shock, severe underlying lung disease, those with PORT Risk Class V, and/or CAP requiring ventilation at presentation, CAP due to methicillin-resistant S. aureus or patients requiring intensive care. Caution is advised when treating such patients.1



Abbreviations
​​​​​​​
CAP, community-acquired pneumonia; cSSTI, complicated skin and soft tissue infections; MRSA, methicillin-resistant Staphylococcus aureus.
References
  1. ZINFORO. Summary of Product Characteristics
  2. Laudano JB. J Antimicrob Chemother 2011;66(Suppl.3):iii11-iii18
  3. Garrison MW, et al. Expert Rev Anti Infect Ther 2012;10:1087-103
  4. Drusano GL, et al. J Antimicrob Chemother 2011;66:iii61-7
  5. Korczowski B, et al. Pediatr Infect Dis J 2016;35:e239–47
  6. Suaya JA, et al. BMC infect Dis 2014;14:296
  7. Cannavino CR, et al. Pediatr Infect Dis J 2016;35:752–59
  8. Dona D, et al. Int J Pediatr 2017; article ID 4239268
  9. Rodrigues CMC. Curr Ther Res Clin Exp 2017;84:e7–11
  10. García-Elorriaga G and Del Rey-Pineda G. J Pediatr Infect Dis 2016;1(1:3)
  11. Harris M, et al. Thorax 2011;66:ii1–23
  12. Williams DJ, et al. Pediatrics 2011;128:e479–87
  13. Moore SJ, et al. Pediatr Infect Dis J 2014;33:825–8
  14. le Roux DM and Zar HJ. Pediatr Radiol 2017;47:1392–8
    15. Schuler CL, et al. Pediatrics 2018;137:e20181420
    16. Ray GT, et al. BMC Infect Dis 2013;13:252
PP-ZFO-GBR-0148. June 2021

Discover specific information on the use of Zinforo in neonates, infants and children here:

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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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PP-PFE-GBR-2688. December 2020

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