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About Zinforo

About Zinforo

OverviewExtended spectrum coverage


Adult & adolescent dosingNeonatal & paediatric dosing
Efficacy & Safety

Efficacy & Safety

EfficacyFOCUS Phase III Trial (CAP)CANVAS Phase III Trial (cSSTI)ASIA CAP Phase III TrialPaediatric EfficacyAdult safetyPaediatric Safety
Clinical & Scientific Data

Clinical & Scientific Data

Patient Risk FactorsCAP patient profilescSSTI patient profilesCAPTURE study
Support & Resources

Support & Resources

Videos & case studiesVideos

Information on how to access prescribing information and adverse event reporting can be found at the bottom of the page.

Zinforo®: High clinical cure rate and evidence of rapid response in CAPClinical cure rates: ASIA CAP2
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Study design

A Phase III, prospective, multicentre (China, Taiwan, Korea, Vietnam and India), randomised, double-blind, non-inferiority with nested superiority trial comparing Zinforo (600 mg IV every 12 hours) vs ceftriaxone (2 g IV every 24 hours)

Patient population

Adult Asian patients ≥18 years of age with PORT risk class III-IV CAP. 763 patients were treated for 5-7 days and evaluated in the MITT population

Study objective

To determine non-inferiority (with nested superiority) in the clinical cure rate of Zinforo compared with ceftriaxone (2 g) in the CE population at TOC (8-15 days after end of treatment)

Secondary objectives

Clinical response at the TOC in the MITT, mMITT, and ME populations; clinical response at EOT; clinical relapse at the LFU visit in patients who were clinically cured at TOC; microbiological response at the TOC; clinical and microbiological response by pathogen at the TOC; and safety (as assessed by adverse events in the safety population)
Clinical cure was defined as total resolution of all signs and symptoms of CAP or improvement to such an extent that further antimicrobial treatment was unnecessary

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Zinforo 600 mg every 12 hours demonstrated superior efficacy vs ceftriaxone 2 g every 24 hours in terms of clinical cure rates2

Non-inferiority was defined as a lower limit of the 95% CI ≥–10% for the between group difference. If this was achieved the protocol stated superiority would be concluded if the lower limit of the 95% CI ≥0%.2

The safety profile of Zinforo was similar to that observed in the pooled Phase III CAP and cSSTI studies.2-4

Explore More Read several CAP patient profiles describing potential scenarios where Zinforo could be a treatment of choice.
Access CAP patient profilesLoading
To learn more about the efficacy of Zinforo in a real-world setting, explore the CAPTURE study. View CAPTURE study dataLoading

**Zinforo is not active against Pseudomonas aeruginosa. Like other cephalosporins, Zinforo is not active against ESBL-producing strains. In vitro activity does not always correlate with clinical efficacy.1


CAP, community-acquired pneumonia; cSSTI, complicated skin and soft tissue infections; CE, clinically evaluable; CI, confidence interval; MITT, modified intent-to-treat; PORT, Pneumonia Patient Outcomes Research Team; MRSA, Methicillin-resistant Staphylococcus aureus.

Prescribing Information​​​​​​​

Zinforo® (ceftaroline fosamil)
Great Britain
Zinforo 600 mg powder for concentrate for solution for infusion
Northern Ireland
Zinforo 600 mg powder for concentrate for solution for infusion 


ZINFORO. Summary of Product CharacteristicsZhong N, et al. Lancet Infect Dis 2015;15:161-71File TM, et al. Clin Infect Dis 2010;51:1395–405Corey G, et al. Clin Infect Dis 2010;51:641-50Laudano JB. J Antimicrob Chemother 2011;66(Suppl.3):iii11-iii18Garrison MW, et al. Expert Rev Anti Infect Ther 2012;10:1087-103Drusano, GL. J Antimicrob Chemother 2011;66(Suppl3):iii61–7
PP-ZFO-GBR-0226. September 2021
Explore the outcomes of the other Zinforo Phase III clinical trials in patients with CAP and cSSTI Tolerability profile of Zinforo 

Access data on the tolerability profile of Zinforo as established in key Phase III clinical trials

View tolerability profile Loading
Zinforo has an extended in vitro spectrum of coverage, including key pathogens in CAP and cSSTI**1,5-7

Learn more about extended spectrum coverage

Adverse events should be reported. Reporting forms and information can be found at or search 

for MHRA Yellow Card in Google Play or Apple App Store


Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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