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CANVAS 1 and 2 trials: Two Phase III, randomised, double-blind, international, multicentre, comparative efficacy and safety trials comparing Zinforo (600 mg IV q12h ± placebo q12h, adjusted for moderate renal impairment) vs vancomycin + aztreonam (1 g IV q12h)2
Response rate at Day 3
Clinical response rates at Day 3 (CANVAS 1 and 2 trials)†3
Zinforo was well tolerated with a safety profile consistent with the cephalosporin class.2
*The lower limit of the 95% CI was above -10%, which met the predefined criteria for non-inferiority.2
‡There is no experience with Zinforo in the treatment of cSSTI in the following patient groups: The immunocompromised; patients with severe sepsis/septic shock; necrotising fasciitis; perirectal abscess; and patients with third-degree and extensive burns. There is limited experience in treating patients with diabetic foot infections. Caution is advised when treating such patients.1
†Zinforo was associated with a non-statistical significant early clinical response defined by cessation of lesion spread and absence of fever.3
**Zinforo is not active against Pseudomonas aeruginosa. Like other cephalosporins, Zinforo is not active against ESBL-producing strains. In vitro activity does not always correlate with clinical efficacy.1
Prescribing Information
Zinforo® (ceftaroline fosamil)
Great Britain
Zinforo 600 mg powder for concentrate for solution for infusion
Northern Ireland
Zinforo 600 mg powder for concentrate for solution for infusion
Access data on the tolerability profile of Zinforo as established in key Phase III clinical trials
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