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Zinforo®: High clinical cure rate and evidence of rapid response in cSSTI

Clinical cure rates: CANVAS 1 and 2

​​​​​​​CANVAS 1 and 2 trials: Two Phase III, randomised, double-blind, international, multicentre, comparative efficacy and safety trials comparing Zinforo (600 mg IV q12h ± placebo q12h, adjusted for moderate renal impairment) vs vancomycin + aztreonam (1 g IV q12h)2

Zinforo 600 mg every 12 hours demonstrated comparable efficacy vs vancomycin plus aztreonam 1 g every 12 hours in terms of clinical cure rates*2 

Zinforo was associated with a trend towards early clinical response when compared to vancomycin + aztreonam at Day 33†

Response rate at Day 3

Zinforo delivers high cure rates in patients with severe disease and comorbidities‡2

Clinical response rates at Day 3 (CANVAS 1 and 2 trials)†3

Zinforo was well tolerated with a safety profile consistent with the cephalosporin class.2

Explore More

Read several cSSTI patient profiles describing potential scenarios where Zinforo could be a treatment of choice.

Access cSSTI patient profiles 

To learn more about the efficacy of Zinforo in a real-world setting, explore the CAPTURE study.

Access CAP patient profiles

*The lower limit of the 95% CI was above -10%, which met the predefined criteria for non-inferiority.2
 There is no experience with Zinforo in the treatment of cSSTI in the following patient groups: The immunocompromised; patients with severe sepsis/septic shock; necrotising fasciitis; perirectal abscess; and patients with third-degree and extensive burns. There is limited experience in treating patients with diabetic foot infections. Caution is advised when treating such patients.1
Zinforo was associated with a non-statistical significant early clinical response defined by cessation of lesion spread and absence of fever.3
**Zinforo is not active against Pseudomonas aeruginosa. Like other cephalosporins, Zinforo is not active against ESBL-producing strains. In vitro activity does not always correlate with clinical efficacy.1​​​​​​​


Abbreviations

​​​​​​​CAP, community-acquired pneumonia; cSSTI, complicated skin and soft tissue infections; CE, clinically evaluable; CANVAS, CeftAroliNe fosamil vs VAncomycin in Skin and skin structure infection; CI, confidence interval; MITT, modified intent-to-treat; PORT, Pneumonia Patient Outcomes Research Team; MRSA, Methicillin-resistant Staphylococcus aureus

Prescribing Information​​​​​​​

Zinforo® (ceftaroline fosamil)
Great Britain
Zinforo 600 mg powder for concentrate for solution for infusion
Northern Ireland
Zinforo 600 mg powder for concentrate for solution for infusion 

Prescribing Information​​​​​​​

Zinforo® (ceftaroline fosamil)
Great Britain
Zinforo 600 mg powder for concentrate for solution for infusion
Northern Ireland
Zinforo 600 mg powder for concentrate for solution for infusion 

References
  1. ZINFORO. Summary of Product Characteristics
  2. Corey G, et al. Clin Infect Dis 2010;51:641-50
  3. Friedland D, et al. Antimicrob Agents Chemother 2012;56:2231-6
  4. Laudano JB. J Antimicrob Chemother 2011;66(Suppl.3):iii11-iii18
  5. Garrison MW, et al. Expert Rev Anti Infect Ther 2012;10:1087-103
  6. Drusano, GL. J Antimicrob Chemother 2011;66(Suppl3):iii61–7
PP-ZFO-GBR-0225. September 2021

Explore the outcomes of the other Zinforo Phase III clinical trials in patients with CAP

Tolerability profile of Zinforo 

Access data on the tolerability profile of Zinforo as established in key Phase III clinical trials

View tolerability profile

** This is an optional area where footnotes can live.

Zinforo has an extended in vitro spectrum of coverage, including key pathogens in CAP and cSSTI**1,4-6

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PP-PFE-GBR-2688. December 2020

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