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Adverse event reporting can be found at the bottom of the page

About Zinforo

About Zinforo

OverviewExtended spectrum coverage
Dosing

Dosing

Adult & adolescent dosingNeonatal & paediatric dosing
Efficacy & Safety

Efficacy & Safety

EfficacyFOCUS Phase III Trial (CAP)CANVAS Phase III Trial (cSSTI)ASIA CAP Phase III TrialPaediatric EfficacyAdult safetyPaediatric Safety
Clinical & Scientific Data

Clinical & Scientific Data

Patient Risk FactorsCAP patient profilescSSTI patient profilesCAPTURE study
Support & Resources

Support & Resources

Videos & case studiesVideos
Materials

Information on how to access prescribing information and adverse event reporting can be found at the bottom of the page.

Zinforo®: a smart choice for patients when there’s no time to waitExplore the outcomes of the Zinforo Phase III clinical trials in patients with CAP and cSSTI ​​​​​​​

Zinforo showed high clinical cure rate and evidence of rapid response in CAP and cSSTI2,3
Explore three Phase III trials here. 

FOCUS Phase III trial (CAP) Loading ASIA CAP Phase III trial  Loading ​​​​​​​CANVAS Phase III trial  Loading

Zinforo targets key pathogens in CAP and cSSTI paediatric patients from birth including Streptococcus pneumoniae (in CAP) and  Staphylococcus aureus (including methicillin-resistant strains in cSSTI and methcillin-susceptible strains only in CAP).*1,8-16

Paediatric efficacy Loading

*There is no experience with Zinforo in the treatment of CAP in the following patient groups: the immunocompromised, patients with severe sepsis/septic shock, severe underlying lung disease (eg cystic fibrosis), those with PORT Risk Class V, and/or CAP requiring ventilation at presentation, CAP due to methicillin-resistant S. aureus or patients requiring intensive care. Caution is advised when treating such patients.There is no experience with ceftaroline in the treatment of cSSTI in the following patient groups: the immunocompromised, patients with severe sepsis/septic shock, necrotizing fasciitis, perirectal abscess and patients with third degree and extensive burns. There is limited experience in treating patients with diabetic foot infections. Caution is advised when treating such patients.1
**Zinforo is not active against Pseudomonas aeruginosa. Like other cephalosporins, Zinforo is not active against ESBL-producing strains. In vitro activity does not always correlate with clinical efficacy.1

Abbreviations

CAP, community-acquired pneumonia; cSSTI, complicated skin and soft tissue infections; CANVAS, CeftAroliNe fosamil vs Vancomycin in Skin and skin structure infection; FOCUS, CeFtarOline Community-acquired pneUmonia trial vS ceftriaxone in hospitalised patients.

Prescribing Information​​​​​​​

Zinforo® (ceftaroline fosamil)

Great Britain
Zinforo 600 mg powder for concentrate for solution for infusion

Northern Ireland
Zinforo 600 mg powder for concentrate for solution for infusion 

References

ZINFORO. Summary of Product CharacteristicsZhong N, et al. Lancet Infect Dis 2015;15:161-71File TM, et al. Clin Infect Dis 2010;51:1395–405Corey G, et al. Clin Infect Dis 2010;51:641-50Laudano JB. J Antimicrob Chemother 2011;66(Suppl.3):iii11-iii18Garrison MW, et al. Expert Rev Anti Infect Ther 2012;10:1087-103Drusano, GL. J Antimicrob Chemother 2011;66(Suppl3):iii61–7Korczowski B, et al. Pediatr Infect Dis J 2016;35:e239–47 Cannavino CR, et al. Pediatr Infect Dis J 2016;35:752–9Suaya JA, et al. BMC infect Dis 2014;14:296Harris M, et al. Thorax 2011;66:ii1–23Dona D, et al. Int J Pediatr 2017; article ID 4239268le Roux DM and Zar HJ. Pediatr Radiol 2017;47:1392–8Schuler CL, et al. Pediatrics 2018;137:e20181420Williams DJ, et al. Pediatrics 2011;128:e479–87Ray GT, et al. BMC Infect Dis 2013;13:252
PP-ZFO-GBR-0223. September 2021
Tolerability profile of Zinforo

Access data on the tolerability profile of Zinforo as established in key Phase III clinical trials 

View tolerability profile Loading
Zinforo has an extended in vitro spectrum of coverage, including key pathogens in CAP and cSSTI**1,4-6

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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