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Zinforo was as effective as comparator therapy in the treatment of paediatric patients aged 2 months to <18 years with cSSTI (N=159), including those caused by MRSA (n=18)*
Dosing:
Zinforo had similar effectiveness to ceftriaxone in the treatment of paediatric patients aged 2 months to <18 years who were hospitalised with CAP (N=143)¶
Dosing:
*Multicentre, randomised, observer-blinded, active-controlled study where the primary objective was to evaluate the safety and tolerability of Zinforo. The study was not powered for comparative inferential efficacy analysis, and no efficacy endpoint was identified as primary.
†Doses of Zinforo were based on paediatric population pharmacokinetic modelling designed to achieve the same antibiotic exposure in children that was shown to be effective in adults.
‡Evaluated 8–15 days after the last dose of any antibiotic (IV or oral).
¶Multicentre, randomised, prospective, comparator-controlled study where the primary objective was to evaluate the safety and tolerability of Zinforo. The study was not powered for comparative inferential efficacy analysis, and no efficacy endpoint was identified as primary.
**Zinforo is not active against Pseudomonas aeruginosa. Like other cephalosporins, Zinforo is not active against ESBL-producing strains. In vitro activity does not always correlate with clinical efficacy.1
Abbreviations
CAP, community-acquired pneumonia; cSSTI, complicated skin and soft tissue infections; CE, clinically evaluable; TOC, test-of-cure; MITT, modified intent-to-treat; IV, intravenous; MRSA, methicillin-resistant Staphylococcus aureus.
Prescribing Information
Zinforo® (ceftaroline fosamil)
Great Britain
Zinforo 600 mg powder for concentrate for solution for infusion
Northern Ireland
Zinforo 600 mg powder for concentrate for solution for infusion
Zyvox (linezolid) 2mg/ml Solution for Infusion
Zyvox (linezolid) 600mg Film-Coated Tablets
Zyvox (linezolid) 100mg/5ml Granules for Oral Suspension
Dalacin C (clindamycin hydrochloride) 150mg capsules
Dalacin C (clindamycin hydrochloride) 75mg capsules
Dalacin C (clindamycin phosphate) sterile solution for injection
Dalacin T (clindamycin phosphate) 1% topical lotion
Dalacin (clindamycin phosphate) 2% cream
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PP-PFE-GBR-3863. November 2021