How does Champix work?

Champix helps to break the pharmacologic basis of addiction1 in two ways, helping patients to be smoke-free and nicotine-free.2-4

Download this mode of action card for reference.

This short video explains more.  

Read about CHAMPIX warnings and precautions

1.  Benowitz NL. Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics. Annu Rev Pharmacol Toxicol 2009; 49: 57-71.
2. CHAMPIX Summary of Product Characteristics.

3. Gonzales D, Rennard Sl, Nides M et al. Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, vs sustained release bupropion and placebo for smoking cessation. A randomized controlled trial. JAMA 2006; 296: 47-55.
4. West R, Baker CL, Cappelleri JC et al. Effect of varenicline and bupropion SR on craving, nicotine withdrawal symptoms, and rewarding effects of smoking during a quit attempt. Psychopharmacology 2008; 197: 371-377.


PP-CHM-GBR-3648.  November 2020