Enbrel dosing and administration

The MyClic pre-filled pen is a simple administration device containing 25 mg or 50 mg of Enbrel. Benefits of MyClic include higher patient adherence, satisfaction and convenience, and increased ease of use, compared with a pre-filled syringe.1

Simple | Sure | Secure2,3

MyClic: Flexible dosing options, with 25mg strength

Only Enbrel offers the range of administration and dosing options with 10 mg (paediatric), 25 mg and 50 mg strengths available.3–6MyClic offers increased flexibility to choose the preferred delivery method for all patient types.5

MyClic: Proven patient benefits1

33% of UK RA patients say that their HCPs underestimate the pain and discomfort of injected medications.7

Among Enbrel patients who had previously used a pre-filled syringe, the MyClic pre-filled pen was associated with:

  • Higher patient satisfaction compared to the pre-filled syringe, including easiness of learning how to use the device (p<0.001) and performing the injection (p<0.001)*8
  • Significantly reduced pain at the injection site: mean VAS score 2.91 vs. 1.77 (p<0.001)†2
  • An adherence level of >95%2
  • An increase from 66% to 93% in patients self-administering Enbrel2
  • A decrease from 23% to 2% in patients requiring nurse assistance in primary care facilities2

MyClic does not interfere with patients’ social lives, leisure and daily activities1

Watch the MyClic administration video.

*In a multi-centre, open-label, randomised, parallel-design study, 421 adult patients with psoriasis were randomised to receive Enbrel 50 mg twice weekly subcutaneously for 12 weeks either as a pre-filled syringe or as a pre-filled pen. The primary outcome was patient satisfaction at week 12 with the injection device as measured on a 0–10 point Likert scale. The study was powered to demonstrate non-inferiority of a pen over a syringe for the primary endpoint.8 38 men and 66 women diagnosed with rheumatoid arthritis (56%), psoriatic arthritis (30%) and ankylosing spondylitis (14%) switched from the 50 mg pre-filled syringe to the 50 mg MyClic pre-filled pen. Patients answered questions during an interview 2 months after starting Enbrel treatment with the MyClic pre-filled pen.2

HCP: healthcare professional; JIA: juvenile idiopathic arthritis; RA: rheumatoid arthritis.

  1. Müller-Ladner U, et al. Z Rheumatol. 2012;71:890–899.
  2. Borrás-Blasco J, et al. Expert Opin Biol Ther. 2013;13:1103–1108.
  3. Enbrel (etanercept) SmPC. 50 mg solution for injection in pre-filled pen. Available at http://www.medicines.org.uk/emc [Accessed October 2017].
  4. Enbrel (etanercept) SmPC. 25 mg powder and solvent for solution for injection. Available at http://www.medicines.org.uk/emc [Accessed October 2017].
  5. Enbrel (etanercept) SmPC. 25 mg solution for injection in pre-filled syringe. Available at http://www.medicines.org.uk/emc [Accessed October 2017].
  6. Enbrel (etanercept) SmPC 10 mg solution for injection. Available at http://www.medicines.org.uk/emc [Accessed October 2017].
  7. Pfizer Data on file. RA NarRAtive Patient Survey Banner.
  8. Paul C, et al. J Eur Acad Dermatol Venereol. 2012;26:448–455.


PP-ENB-GBR-0880 October 2018

  • 25 mg and 50 mg
  • Clear glass syringe (type I glass) with stainless steel needle, rubber needle cover and plastic plunger
  • Cartons contain 4 pre-filled syringes of Enbrel and 4 alcohol swabs

PP-ENB-GBR-0880 October 2018

  • 10 mg and 25 mg
  • Clear glass vial (4 ml, type I glass) with rubber stopper, aluminium seal, and flip-off plastic cap
  • Powdered Enbrel is supplied for use with pre-filled syringes containing a solvent (water) for injection
  • Cartons contain 4 vials of Enbrel with 4 pre-filled solvent syringes, 4 needles, 4 vial adaptors and 8 alcohol swabs

PP-ENB-GBR-0880 October 2018