Unstable Angina and NSTEMI: Dosing


Use of Fragmin® in patients with unstable angina and non-ST-elevation MI


Unstable angina and NSTEMI administered concurrently with aspirin1

Acute stage1


•Recommended dose: 120 IU/kg body weight s.c. 12 hourly for up to 8 days

•Max dose: 10,000 IU/12 hours

Extended use:

•Fragmin® may be used beyond 8 days (i.e. for those awaiting angiography/revascularisation procedures). To be given until the day of revascularisation procedure, percutaneous transluminal coronary angioplasty [PTCA] or coronary artery bypass graft [CABG]) but not for >45 days

Recommended dose in extended use:1

Recommended Dose in Extended Use


1. Fragmin SmPC [Unstable Angina (Graduated syringe 10,000 IU/ml solution for injection, 10,000 IU/1 ml ampoule, 7,500 IU)]. Available at: https://www.medicines.org.uk/emc/search?q=fragmin

*Including, but not limited to: congestive cardiac failure (NYHA class III or IV), acute respiratory failure or acute infection, who also have a predisposing risk factor for VTE such as age over 75 years, obesity, cancer or previous history of VTE.~
†In patients with chronic renal insufficiency or acute renal failure.

PP-FRA-GBR-0162.  June 2019