Genotropin (somatropin, rbe) delivery portfolio

Devices that work together for different needs and situations

Genotropin comes in a range of different delivery devices, designed to suit patients throughout their treatment course.

Our range of devices work together, to provide for different needs and situations that your patients will experience – whether for young children attending school, or young adults experiencing travel or situations where a fridge may not be available.

Easy to use, easy to learn devices

One of the main concerns patients have when starting their therapy is centred around injections. The Genotropin delivery devices are designed to be easy to use and learn, so that patients can feel confident about administering therapy.

GoQuick

MiniQuick

Pen

Pre-filled
Pre-settable
Simple three-stage reconstitution

Discreet and portable
No refrigeration required (can be stored at or below 25°C for up to 6 months).
Pre-filled single use

Customisable
Digital dose display

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For more information about using any of the Genotropin delivery devices please see the relevant training manual or contact your local Pfizer Endocrine Care representative on 0800 521249, or to request a visit, please click here.

PP-GEN-GBR-0467. July 2018

 

Genotropin GoQuick – Providing simplicity and convenience

The GoQuick device is designed to meet individual dosing requirements and to suit patients’ needs.

Just three easy steps are required for everyday use of Genotropin GoQuick

  1. Attach the needle
  2. Dial up to the pre-set dose
  3. Give the injection

Genotropin GoQuick pen helps to make somatropin growth hormone treatment predictable by delivering the correct dose simply and reliably, time after time.

Patient demonstration videos

To help reinforce your training, Pfizer UK provides educational videos for patients to watch, giving step-by-step instructions on the use of the Genotropin GoQuick. 

Repeated viewing of the training videos can help to reinforce your instructions, improving patient confidence and adherence.

These videos can be sent out to new patients as a DVD and as part of their starter pack, and can be reviewed below.

Please visit the helpline page for more information on how to order a starter pack for your patients.

Genotropin GoQuick - Designed with patient confidence in mind1,2

Pre-filled and disposable

  • No cartridge loading avoids complicated steps and saves time
  • No cartridge loading simplifies the process of training patients
  • Simple step-by-step reconstitution of product (twist from A to B to C)

Pre-settable dosing

  • Allows the correct dose to be given every time
  • Gives patients reassurance that the correct dose is being administered, regardless of who is injecting
  • Gives prescriber confidence that the correct dose is given every time, regardless of who is injecting
  • No daily dose setting reduces injection time and minimises mistakes
 

Needle guard (optional)

  • Hides the needle, reducing anxiety for needle-shy children and parents
  • Makes the device easier to hold steady, helping with confident administration

GoQuick Dosing Information

The GoQuick is available in two presentations: 5.3mg & 12mg

The GoQuick pen comes in two different colours to represent the two different licensed presentations. This helps to ensure that patients can quickly identify and check that they have been dispensed the correct dosage.

  • Blue GoQuick Pen: 5.3mg
  • Purple GoQuick Pen: 12.8mg

All GoQuick pens are prepared and used in the same way. 

Dosing details for 12mg* GoQuick Pen1,2

The following dosing guide will assist prescribers in determining the correct daily dose for patients using the GoQuick Pen.

Daily dose (mg)†

Days per cartridge

Final dose in cartridge on last day

0.20

26

0.20

0.25

20

0.20

0.30

17

0.10

0.35

14

0.30

0.40

13

0.40

0.45

11

0.25

0.50

10

0.20

0.55

9

1.25

0.65

8

0.65

0.70

7

0.30

0.85

6

0.10

1.00

5

0.20

1.25

4

0.20

*5.3mg pen contains 5.2mg, plus 0.1mg for use in the priming step.

†The dose displayed on the pen is in 0.1mg increments. Each dash equates to a 0.05mg increase on the previous increment.

Before reconstitution: The GoQuick pen should be stored in a refrigerator at between 2-5°C or for up to 1 month at room temperature (25°C). Protect from light.

After reconstitution: The GoQuick pen should be stored in a refrigerator at between 2-5°C. Protect from light and use within 4 weeks.

 

Dosing details for 12mg* GoQuick Pen1,2

The following dosing guide will assist prescribers in determining the correct daily dose for patients using the GoQuick Pen.

Daily dose (mg)†

Days per cartridge

Final dose in cartridge on last day

0.45

26

0.45

0.60

20

0.30

0.75

16

0.45

0.90

13

0.90

1.05

12

0.15

1.20

10

0.90

1.35

9

0.90

1.50

8

1.20

1.80

7

0.90

1.95

6

1.95

2.40

5

2.10

3.00

4

2.70

*12mg pen contains 11.7mg, plus 0.3mg for use in priming step.

†The dose displayed on the pen is in 0.3mg increments. Each dash equates to a 0.15mg increase on the previous increment.

Before reconstitution: The GoQuick pen should be stored in a refrigerator at between 2-5°C or for up to 1 month at room temperature (25°C).  Protect from light.

After reconstitution: The GoQuick pen should be stored in a refrigerator at between 2-5°C. Protect from light and use within 4 weeks.

PP-GEN-GBR-0467. July 2018

 

The Genotropin MiniQuick Device

The Genotropin MiniQuick contains a single dose of somatropin growth hormone and is a discreet, portable, single use device. It’s small and simple to use, and doesn’t have to be stored in a fridge before the growth hormone is mixed, making it ideal for use when away from home or travelling.

Benefits for patients and healthcare professionals: 1-3

Easy to use

  • Pre-filled and disposable1
  • Four simple steps ease training and everyday use 1,2
  • Safety pen needles with built in needle cover for discreet dose delivery are available

Precise pre-filled doses

  • Single fixed dose – no dose setting required,3 reducing risk of incorrect dosing
  • Available in 10 different strengths (0.2 – 2mg)3
  • Provides simplicity for the patient2, combined with dosage accuracy for the healthcare professional

No refrigeration required

  • Can be stored at or below 25°C by the end user for up to 6 months3
  • After reconstitution, can be stored in a refrigerator (2–8°C) for up to 24 hours3
  • Packaged in a 7-day supply to simplify therapy

Suitable for a range of patients

  • Young adults going to college or university
  • Patients with learning difficulties
  • Patients who speak a different language
  • Where compliance issues are anticipated
  • Working life involves time away from home
  • Holiday or travel limits access to fridge

Preservative-free

  • Does not contain preservatives1

How to use the Genotropin MiniQuick

Each pack contains patient information and directions for use. In addition, Pfizer UK has provided a patient instruction video on DVD that can be sent to patients on request. Home care visits can also be arranged for device training, on request

Patient demonstration videos

To help reinforce your training, Pfizer UK provides educational videos for patients to watch, giving step-by-step instructions on the use of the Genotropin MiniQuick. 

Repeated viewing of the training videos can help to reinforce your instructions, improving patient confidence and adherence.

These videos can be sent out to new patients as a DVD and as part of their starter pack, and can be reviewed below.

Please visit the helpline page for more information on how to order a starter pack for your patients.

Training Guide for Genotropin MiniQuick Use.1,3

Healthcare providers should include the following information when counselling patients on Genotropin MiniQuick Use.

Please note: Patients and/or carers should always be cautioned that waste from injections must be disposed of in a sharps bin rather than an ordinary bin at all times.

Step one – adding a needle

Patients should be advised to attach a new needle by pushing and screwing the outer needle cap onto the end of the syringe. Provided needles may be yellow or blue capped, although the education video includes yellow ones as an example. Once the needle has been screwed on, patients (or carers) should pull off the outer needle cap and discard it in a sharps bin. 

Step two – preparing the syringe for injection

To prepare the syringe for injection, patients should hold the syringe upright and screw the white plunger clockwise until it cannot be turned any more. This action mixes together the solvent and powdered somatropin growth hormone. 

Patients should check that the powder has completely dissolved by inspecting the syringe chamber. If the growth hormone powder has not fully dissolved, patients should be advised to give the syringe a few gentle taps and to tilt the syringe gently from side to side, taking care not to shake it.

Step three – injecting

The inner needle cap should now be removed and safely disposed of within the sharps bin.

After preparing the injection site, patients should insert the needle straight down into the injection site. When injecting, patients should push the plunger all the way down, with the needle held in place for at least five seconds before removing it.

The MiniQuick can now be disposed of in the sharps bin.

Storage

Although the Genotropin MiniQuick does not need to be stored in a fridge prior to mixing, patients should be instructed that if the MiniQuick is not going to be used immediately, it must be stored in a fridge and used within a 24 hour period.

References

1. Genotropin Package Leaflet

2. Data on file, MiniQuick Switch / Preference Study

3. Genotropin MiniQuick Summary of Product Characteristics

 

PP-GEN-GBR-0467. July 2018

 

The Genotropin Pen®

Simplicity and flexibility in human growth hormone administration

The original Genotropin pen has been chosen by patients for more than 15 years, and is designed to make taking growth hormone simple and straight forward. 

Simple and adjustable dosing

Two dosage formats: Genotropin pen cartridges are available in two dosage presentations: 5.3mg and 12mg strengths.

  • Patients requiring a dose of under 0.5 mg/day should use the 5.3 mg pen
  • Patients requiring a higher dose should use the 12 mg pen

Digital dose display: ensures correct and accurate dosing 

Dial-back mechanism: facilitates error correction and reduces waste

Quick and easy administration

  • Needle guard: Genotropin pen comes with an optional needle guard to hide the needle from view for patients who are anxious about needles.
  • Colour Coding: Cartridges are colour coded to facilitate easy confirmation that the correct dose of somatropin has been dispensed.
  • Self-mixing growth hormone powder: Self-mixing powder automatically dissolves when a cartridge is loaded.
  • Small injection volume

Easy Storage

  • The Genotropin pen comes in a hard protective case, which can be used for every day storage or transportation.
  • Once loaded the Genotropin pen should be stored in the refrigerator at 2-8°C along with any cartridges.

Customisation

Unique features of the Genotropin pen allow personalisation and customisation to encourage compliance.

  • Clip-on panels (Geno-Caps®): Each pen comes with two interchangeable side panels or ‘Geno-caps’ with matching lids, to allow patients to select or change their pen colour. 
  • Individualisation: The Genotropin pen includes a small hole near the injection button that allows for further personalisation with (for example) charms.

Genotropin Pen – Easy to use and simple training

The Genotropin pen has been designed to help users introduce it into daily life using four easy steps each day.

  1. Attach the needle
  2. Press the red button
  3. Dial up a dose
  4. Give the injection

Patient demonstration videos

To help reinforce your training, Pfizer UK provides educational videos for patients to watch, giving step-by-step instructions on the preparation and use of the Genotropin Pen. 

Repeated viewing of the training videos can help to reinforce your instructions, improving patient confidence and adherence.

These videos can be sent out to new patients as a DVD and as part of their starter pack, and can be reviewed below.

Please visit the helpline page for more information on how to order a starter pack for your patients.

Training Guide for Genotropin Pen Use

A. Setting up the pen – inserting a cartridge

This procedure should be followed by patients when setting up a Genotropin pen for the first time, or when replacing a cartridge.

  1. Instruct patients (or carers) to find and press the red button on the side of the pen, which releases the black injection button from its locked position.
  2. Now, remove the lid from the pen so that the cartridge holder can be unscrewed from the pen. If replacing an empty cartridge, once the holder has been removed, the cartridge can be unscrewed from the holder and discarded into a sharps bin.
  3. To reset the pen mechanism, instruct patients to gently turn the injection button anticlockwise until it cannot be turned any further. It should not be possible to see the plunger rod in the window at the front of the pen.
  4. The injection button should now be turned clockwise until it clicks, and the white mark on the injection button is aligned with the grey mark on the pen.

The pen is now ready to have the needle attached.

B. Attaching the needle

  1. Instruct users to remove the foil from a fresh needle unit, and attach it to the cartridge holder by pushing and screwing it on. Make sure that patients are aware that the needle cap should be kept on at this stage.
  2. On taking out a new cartridge, users should check that the number of milligrams and the colour match those of the pen.
  3. With the cartridge holder upright, users should be instructed to insert the cartridge firmly, powder end first. Holding the pen with the needle pointing vertically upright, the two parts of the pen can then be screwed together.

C. Mixing the somatropin growth hormone with solvent

The Genotropin comes in two parts: a liquid solvent and powdered growth hormone which need to be mixed together before use. This should happen automatically on screwing the cartridge into place. To check that this has occurred satisfactorily:

  1. Users should check the cartridge window to see that the solvent and powder have mixed fully and that the powder is properly dissolved. If further mixing is required, the pen should be tipped gently from side to side without shaking.
  2. Users should also check that the dissolved product appears ‘clear’. If the appearance of the solution is cloudy, the medicine should not be used and must be safely discarded in their sharps bin.  Users should then simply replace the faulty cartridge with a new one and contact their doctor or nurse.

D. Removing the air from the pen.

  1. Users should take off the outer needle cover and put it in a safe place; next they should remove the inner needle cover and discard it in the sharps bin. Caution patients that the needle needs to be kept sterile and is sharp, so care must be taken. 
  2. Advise patients to hold the pen in a vertical position and gently tap the top of the pen and watch for air bubbles. Once all air bubbles have risen, they should press the black and white injection button fully so that a small amount of liquid is ejected.  If no liquid emerges, press the red release button, turn the injection button one click clockwise, and press the injection button again. Repeat if necessary, until some liquid has emerged. Once the air has been successfully removed, the pen is loaded and ready for use on a day-to-day basis.

E. Preparing for the daily injection

  1. Before injecting, patients should remove the outer needle cover and place it on one side safely for later use. The inner needle cover can now be removed and discarded in the sharps bin.
  2. Patients should now remove any excess air, as described in point ‘D’ above. The pen is now ready for injection.

If using a needle guard, this can be added at this point to the Genotropin pen. The needle guard will hide the needle from view during an injection and can be used for each injection for the lifetime of the pen.

  1. First patients should press the red release button on the side of the pen to release the injection button and switches on the dose display.
  2. To set the dose, users should turn the injection button clockwise until the correct dose appears on the display.

F.  Injecting the Genotropin

  1. To inject, advise patients or their carer to push the pen straight down into the skin at an injection site that has been prepared in accordance with healthcare provider instructions.
  2. Patients should use their thumb to push the injection button down until it clicks in the locked position, and should count for 10 seconds before the needle is pulled straight up out of the skin.

G. Removing the needle

If using a needle guard, this should be removed first and prior to attempting needle removal.

  1. Using the outer needle cap, push the cap onto the end of the cartridge holder so that it covers the needle.
  2. Whilst squeezing the sides of the cap twist the needle anticlockwise to unscrew it.  The needle will stay inside the needle cap, and the cap and needle should be safely disposed of in the sharps bin.
  3. Patients should then replace the Genotropin pen lid, before replacing the pen in its box and storing the pen in the refrigerator until the next dosage.

For more information about using the Genotropin Pen please see the training manual or contact your local Pfizer Endocrine Care representative.

 

PP-GEN-GBR-0467. July 2018