RECLAIM
RECLAIM: Efficacy and safety of ceftazidime-avibactam plus metronidazole versus meropenem in the treatment of cIAI1
As effective as a carbapenem when combined with metronidazole in hospitalised patients with Gram-negative cIAIs1
An international, non-inferiority, randomised, double-blind, comparative, Phase III trial.1
• ZAVICEFTA plus metronidazole versus meropenem
Trial population:1
• cIAI requiring surgical intervention or percutaneous draining within 24 hours before or after randomisation
– Randomised patients, N=1066
– mMITT population, N=1043
Abbreviations:
AE, adverse event; CI, confidence interval; cIAI, complicated intra-abdominal infection; cUTI, complicated urinary tract infection; HAP, hospital-acquired pneumonia; mMITT, microbiologically modified intention-to-treat; VAP, ventilator-associated pneumonia.
Reference:
1. Mazuski JE, et al. Clin Infect Dis 2016;62:1380–9
*The 2 combined studies were sized to provide 90% power for a 10% non-inferiority margin and thus 95% power for a 12.5 non-inferiority margin.
†Patients in the mMITT population are defined as carrying a pathogen at the start of treatment.
Prescribing Information
Zavicefta▼ (ceftazidime avibactam) Prescribing Information
ZAVICEFTA® 2 g/0.5 g Powder for Concentrate for Solution for Infusion
Legal Category: Prescription Only Medicine (POM)
NHS Price: 10 vial pack £857.00.
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Meronem IV (meropenem) Prescribing Information
Meronem IV 1g
Legal Category: Prescription Only Medicine (POM).
NHS Price: 10 vial pack £206.28
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Meronem IV 500mg
Legal Category: Prescription Only Medicine (POM).
NHS Price: 10 vial pack £103.14
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Tygacil® (tigecycline) Prescribing Information
Tygacil® 50 mg Powder for Solution for Infusion
Legal Category: Prescription Only Medicine (POM)
NHS Price: 10 vial pack £323.10
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Tazocin® (piperacillin sodium, tazobactam sodium) Prescribing information
Tazocin® 2 g/0.25 g Powder for Solution for Infusion
Legal Category: Prescription Only Medicine (POM)
NHS Price: 1 vial pack £7.65
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Tazocin® 4 g/0.5 g Powder for Solution for Infusion
Legal Category: Prescription Only Medicine (POM)
NHS Price: 1 vial pack £15.17
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PP-ZVA-GBR-1056. December 2020