Zavicefta (ceftazidime and avibactam): Complicated Intra-Abdominal Infection

Identifying patients with cIAI at high-risk of MDR Gram-negative infections

cIAI Potential Zavicefta Patient

Michael
75-year-old male

Patient History 
  • Type II diabetes mellitus
  • Underwent segmental colon resection/primary anastomosis with peri-operative antibiotic therapy
  • Previous broad-spectrum IV antibiotic use
  • Recent travel
Symptoms
  • Acute-onset abdominal pain developing into diffuse pain
  • Fever
  • Loss of appetite
  • Nausea
Diagnosis
  • ICU admission
  • Complicated diverticulitis
  • Diarrhoea
Suspected pathogens
  • MDR Gram-negative pathogens including K. pneumoniae, possibly carbapenem-and colistin-resistant

 

The example described here is not an actual patient, but rather a fictitious representation of a scenario for which ZAVICEFTA® could be considered. 

 

Risk factors for MDR Gram-negative infection1-5

cIAI Risk Factors

References

1. Bassetti M, et al. Exp Rev Anti Infect Ther 2017;15:55–65; 
2. Miller BM, et al. Am J Infect Control 2016;44:134–7; 
3. De Waele J, et al. Intensive Care Med 2018;44:189–96; 
4. Albur M, et al. Ann Clin Microbiol Antimicrob 2016;15:23; 
5. Harris AD, et al. Emerg Infect Dis 2007;13:1144-9.

Prescribing Information

Zavicefta▼ (ceftazidime avibactam) Prescribing Information
ZAVICEFTA® 2 g/0.5 g Powder for Concentrate for Solution for Infusion
Legal Category: Prescription Only Medicine (POM)
NHS Price: 10 vial pack £857.00.
Click here for the Summary of Product Characteristics 

Meronem IV (meropenem) Prescribing Information
Meronem IV 1g 
Legal Category: Prescription Only Medicine (POM). 
NHS Price: 10 vial pack £206.28
Click here for the Summary of Product Characteristics 
Meronem IV 500mg
Legal Category: Prescription Only Medicine (POM). 
NHS Price: 10 vial pack £103.14
Click here for the Summary of Product Characteristics 

Tygacil® (tigecycline) Prescribing Information 
Tygacil® 50 mg Powder for Solution for Infusion
Legal Category: Prescription Only Medicine (POM)  
NHS Price: 10 vial pack £323.10  
Click here for the Summary of Product Characteristics 

Tazocin® (piperacillin sodium, tazobactam sodium) Prescribing information
Tazocin® 2 g/0.25 g Powder for Solution for Infusion
Legal Category: Prescription Only Medicine (POM) 
NHS Price: 1 vial pack £7.65 
Click here for the Summary of Product Characteristics 
Tazocin® 4 g/0.5 g Powder for Solution for Infusion
Legal Category: Prescription Only Medicine (POM)
NHS Price:  1 vial pack £15.17  
Click here for the Summary of Product Characteristics 

PP-ZVA-GBR-1056.  December 2020