RECAPTURE: Ceftazidime-avibactam versus doripenem for the treatment of cUTI, including acute pyelonephritis1
As effective as a carbapenem in hospitalised patients with Gram-negative cUTIs1
An international, non-inferiority, randomised, double-blind, comparative, Phase III trial1
• ZAVICEFTA versus doripenem
• cUTI, including acute pyelonephritis
– Randomised patients, N=1033
– mMITT population, N=810
*Non-inferiority of ceftazidime-avibactam versus doripenem was demonstrated for the FDA co-primary endpoints (prespecified margin of −10%), as well for the EMA primary endpoint (prespecified margin of −12.5%). The lower limit of the 2-sided 95% CI for the treatment difference for the EMA primary endpoint was also >0%, showing superiority of ceftazidime-avibactam at the 5% significance level.
†Patients in the mMITT population comprised those with minimum disease criteria and eligible baseline pathogen(s).
AE, adverse event; CI, confidence interval; cIAI, complicated intra-abdominal infection; cUTI, complicated urinary tract infection; EMA, European Medicines Agency; HAP, hospital-acquired pneumonia; mMITT, microbiologically modified intention-to-treat; VAP, ventilator-associated pneumonia.
1. Wagenlehner FM, et al. Clin Infect Dis 2016;63:754–62
Meronem IV 1g – SPC
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Meronem IV 500mg – SPC
Legal Category: POM. Basic NHS Cost: 10 vial pack £103.14
Tazocin 2 g/0.25 g Powder for Solution for Infusion – SPC
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Tazocin 4 g/0.5 g Powder for Solution for Infusion – SPC
Legal category: POM. Basic NHS cost: 1 vial pack £15.17
Tygacil 50 mg Powder for Solution for Infusion – SPC
Legal Category: POM. Basic NHS Cost: 10 vial pack £323.10
ZAVICEFTA® 2 g/0.5 g Powder for Concentrate for Solution for Infusion – SPC
Legal category: POM. Basic NHS price: 10 vial pack £857.00.
PP-ZVA-GBR-0700. October 2019