Heart with magnifying glass revealing a maze in a ventricle, alongside text reading 'ATTR-CM suspect & detect, uncover the clues for diagnosis'

Home > Diagnosis of ATTR-CM > Recognising signs and symptoms of ATTR-CM


Recognising signs and symptoms of Transthyretin Amyloid Cardiomyopathy (ATTR-CM)


Patients with wild-type ATTR and hereditary ATTR present with heart failure, particularly heart failure with preserved ejection fraction (HFpEF),1,2,3 and other cardiac symptoms.3-6

| Common signs and symptoms in wild-type ATTR and hereditary ATTR3,4,7-11


A diagram containing two bodies, showing front and back profiles, with arrows pointing to various body parts, indicating the signs and symptoms of ATTR-CM

Adapted with permission from Wolters Kluwer Health, Inc3

| Investigating heart failure with preserved ejection fraction and infiltrative cardiac disease

Prof. Perry Elliot of Bart’s Heart Centre summarises his symposium speech, presenting the key characteristics to help identify HFpEF and explore the potential causes.

Professor Perry Elliott, Professor of Cardiovascular Medicine, University College London and Research Lead of the Inherited Cardiovascular Disease Unit, Bart’s Heart Centre

This symposium at the BCS Annual Conference 2019 was an educational symposium organised and sponsored by Pfizer. The content of the symposium was developed and agreed by the faculty.

| Cardiac

  • Fatigue
  • Shortness of breath
  • Oedema
  • Arrhythmias
  • HFpEF
  • Aortic stenosis
  • Orthostatic hypotension
  • Erectile dysfunction

| Soft tissue

  • Lumbar stenosis
  • Ruptured distal biceps tendon
  • Eye involvement – glaucoma, intravitreal deposition, scalloped pupils

| GI

  • Diarrhoea
  • Constipation
  • Nausea
  • Early satiety

| Neurologic

  • Carpal tunnel syndrome (CTS)
  • Sensory-motor polyneuropathy
  • Weakness