NOR-SWITCH was a randomised, double-blind, non-inferiority parallel-group study that compared the effect of switching from Remicade®†  to Infelctra®/CT-P13* (infliximab) in 481 patients across all indications17.

NOR-SWITCH: Quote from Jorgensen KK; et al

Efficacy

Primary endpoints: Disease worsening across all indications at Week 5217.

Non inferiorityin disease worsening17

Disease worsening at Week 52#17

Efficacy Results

Stable patients switching to CT-P13* experienced a similar percentage of disease worsening when measured across all indications compared to those remaining on Remicade® therapy17.

Safety

There was a similar adverse event profile in stable patients switching from Remicade®† to CT-P13*, compared with those remaining on Remicade®∏17.

Treatment-emergent adverse events17

Safety Results

Prescribing Information 

Inflectra® Summary of Product Characteristics   |   Legal Category: POM  Basic NHS Price: 1 vial £377.66

†Remicade® is a registered trademark of MSD.
*CT-P13 is marketed under different brand names including INFLECTRA® and REMSIMA®.
∏Only single one-way switching from Remicade® to CT-P13* was examined in this study. The NOR-SWITCH trial included only patients on Remicade® and CT-P13*; its findings do not support that any other biosimilars of infliximab can achieve the same result.
‡According to a pre-specified margin of 15%. The study was not powered to show non-inferiority in individual diseases.
#Primary endpoint.

CI, Confidence interval; TNF, Tumour necrosis factor.

 

PP-IFA-GBR-0311. December 2018