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Information relating to specific disease areas aligned to Pfizer’s portfolio and other resources designed for Pfizer medicines.

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Click here for Somavert® (pegvisomant) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

Typical characteristics of acromegaly1,2

Local tumor effects

Visual impairment, headaches, pituitary infarction/destruction, optic/cranial nerve impingement


Soft-tissue swelling, fatigue, enlarged organs

Cutaneous and soft tissue

Enlarged hands, ‘spade-like’ fingers, feet, nose, coarsening of facial features, thick oily skin, increased sweating and skin odour, sweaty handshake, skin tags, increased heel pad thickness, thick lips and skin folds


Carbohydrate intolerance, diabetes mellitus, hyperlipidaemia, goitre, hyperprolactinaemia, galactorrhoea


Congestive heart failure, hypertension, cardiomyopathy, left ventricular hypertrophy


Sleep apnoea, tongue enlargement, voice change


Colonic polyps, diverticulosis


Paraesthesia, somnolence, carpal tunnel syndrome


Malocclusion, widely spaced teeth, prognathism, frontal bossing, enlarged sinuses and larynx, weakness, joint pains (shoulders, back, knees), osteoarthritis, degenerative arthritis of the spine, hips and knees


Decreased libido, impotence, menstrual disturbance, depression, mania

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To find out more about ACRODAT, supporting your patients or to order starter kits 

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Have your heard about ACRODAT?

An acromegaly specific Disease Activity Tool that can help monitor patients at every stage of their journey

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  1. Aron DC, Findling JW, Tyrrell JB. Hypothalamus and pituitary. In: Greenspan FS, Gardner DG., editors. Basic and clinical endocrinology. 6th ed. Lange Medical Books/ McGraw-Hill Medical Publishing Division; 2001. p. 100-162.
  2. Melmed S, Kleinberg D. Anterior pituitary. In: Larsen PR, Kronenberg HM, Melmed S et al., editors. Williams textbook of endocrinology. 10th ed. Philadelphia, Pennsylvania: Saunders (Elsevier); 2003. p. 180-238.
PP-SOM-GBR-0950. June 2021

Acromegaly co-morbidities webinars

Watch and listen to our Rare Disease Insight series where expert speakers take a deep dive into the co-morbidities associated with acromegaly

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Colonic screening in acromegaly

Professor Aled Rees, Consultant in Endocrinology, University Hospital of Wales, Cardiff, explains how active acromegaly can increase the risk of colon cancer and shares a colon surveillance algorithm

Watch more expert webinars

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PP-PFE-GBR-2688. December 2020