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What is acromegalyHow is it diagnosedCharacteristicsSupport & ResourcesVideosMaterials

Click here for Somavert® (pegvisomant) Prescribing Information. 

Typical characteristics of acromegaly1-3Local tumor effects

Visual impairment, headaches, pituitary infarction/destruction, optic/cranial nerve impingement​​​​​​​

General

Soft-tissue swelling, fatigue, enlarged organs

Cutaneous and soft tissue

Enlarged hands, feet and nose, ‘spade-like’ fingers and toes, coarsening of facial features, thick oily skin, increased sweating and skin odour, sweaty handshake, skin tags, increased heel pad thickness, thick lips and skin folds

Endocrine/metabolic

Carbohydrate intolerance, diabetes mellitus, hypertriglyceridemia, goitre, hyperprolactinaemia, galactorrhoea

Cardiovascular

Congestive heart failure, hypertension, cardiomyopathy, left ventricular hypertrophy

Respiratory

Sleep apnoea, tongue enlargement, voice change​​​​​​​

Gastrointestinal

Colonic polyps, hypertrophic mucosal folds and colonic hypertrophy

Neurological

Paraesthesia, somnolence, carpal tunnel syndrome​​​​​​​

Musculoskeletal

Malocclusion, widely spaced teeth, prognathism, frontal bossing, enlarged sinuses and larynx, weakness, joint pains, osteoarthritis, degenerative arthritis of the spine, hips and knees

Psychosexual

Decreased libido, impotence, menstrual disturbance, depression, mood swings, apathy

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References:Aron DC, Findling JW, Tyrrell JB. Hypothalamus and pituitary. In: Greenspan FS, Gardner DG., editors. Basic and clinical endocrinology. 6th ed. Lange Medical Books/ McGraw-Hill Medical Publishing Division; 2001. p. 100-162.Melmed S, Kleinberg D. Anterior pituitary. In: Larsen PR, Kronenberg HM, Melmed S et al., editors. Williams textbook of endocrinology. 10th ed. Philadelphia, Pennsylvania: Saunders (Elsevier); 2003. p. 180-238.Melmed S. Acromegaly. In Melmed S, editor. The pituitary. 4th ed. Philadelphia: Elsevier; 2017. p. 423-466.
PP-SOM-GBR-1316. January 2024.
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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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