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Information relating to specific disease areas aligned to Pfizer’s portfolio and other resources designed for Pfizer medicines.

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Click here for Somavert® (pegvisomant) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

Diagnosis

Presentation

Most patients have unrecognised signs and symptoms for many years and may be diagnosed through a dental examination or testing done for other reasons.Although their outward appearance may have altered, it is often the symptoms of complications that lead patients to seek medical care.

Diagnostic blood tests

The diagnosis can be confirmed with an Oral Glucose Tolerance Test (OGTT) or measurement of serum IGF-I levels (age and sex-adjusted). Although both growth hormone (GH) and IGF-I levels have been implicated as indicators of mortality, IGF-I is considered to be indicative of persistent clinical disease activity.2,3

Imaging

Imaging techniques such as computed tomography (CT) or magnetic resonance imaging (MRI) are used to determine the cause of GH overproduction and provide further confirmation of the acromegaly diagnosis.4

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Treating acromegaly​​​​​​​

By using Somavert and titrating the doses, you can help find your acromegaly patients'​​​​​​​ personal optimum

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References:
  1. Freda PU. Acromegaly diagnostic pitfalls. The Endocrinologist. 2004; 14(5):277-287.
  2. Alexopoulou O, Bex M, Abs R et al. Divergence between growth hormone and insulin-like growth factor-I concentrations in the follow-up of acromegaly. J Clin Endocrinol Metab. 2008; 93(4):1324-1330.
  3. Melmed S, et al. A Consensus Statement on acromegaly therapeutic outcomes. Nat Rev Endocrinol 2018;26:1.
  4. Ilie I, et al. Diagnosis of Acromegaly. Encyclopedia of Endocrine Diseases, Second Edition Vol 2 (Elsevier). 2018 p223-229
PP-SOM-GBR-0950. June 2021

Why target IGF-I?

Professor AJ van der Lely. Erasmus MC, Rotterdam, Netherlands, explains the vital role of IGF-I, the liver and insulin production in acromegaly and its treatment

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PP-PFE-GBR-2688. December 2020

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