Atopic dermatitis (AD), also known as atopic eczema or eczema, is one of the most common chronic inflammatory skin conditions, affecting people of all ages and genders around the world.1,2
AD is a chronic, relapsing inflammatory skin disease with a complex pathophysiology that is characterized by skin that is dry and intensely itchy.3-5
The key cytokines IL-4, IL-13, IL-31, TSLP and IL-22 are believed to drive inflammation, itch, and skin-barrier disruption.3,6,7
Signal transmission is via the JAK/STAT pathway.3,6,7
Prognosis in patients with AD is generally favourable9. However, patients with severe, widespread disease and concomitant atopic conditions (e.g. asthma, allergic rhinitis) may experience poorer outcomes.
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PP-PFE-GBR-3863. November 2021