Transthyretin Amyloid Cardiomyopathy (ATTR-CM) is a rare, and ultimately fatal disease, characterised by the deposition of amyloid fibrils in the myocardium, leading to heart failure.1,2
This is a series of animated, educational modules that outline key background information on ATTR amyloidosis. This video reviews the biological foundation and disease mechanism of ATTR amyloidosis.
Symptoms onset typically over the age of 50-60 years and include:3,4
Cardiac signs include arrhythmias, thickening of the ventricular walls and interventricular septum, as well as cardiomyopathy, resulting in heart failure.4
The disease results in considerable physical and emotional impact for patients and their carers across multiple domains.5
In the UK there is a delay to diagnosis (>4 years in 42% of cases of wild-type ATTR-CM). Barriers to diagnosis are thought to be a major reason for shortened survival with patients using hospital services a median (interquartile range) of 17 (9–27) times during the 3 years before diagnosis; by which time physical function and quality of life is greatly depleted.2
At this point, the prognosis of patients with ATTR-CM is poor; median survival in the UK varies between 2 and 5.5 years.2,6,7
The prognosis worsens with continued amyloid deposits, therefore early diagnosis is key to improving patient outcomes.1,6
Listen to our faculty of expert speakers and download resources including our interactive ATTR-CM Red Flags guide. You can also access and sign up to upcoming virtual events.
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