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About ATTR-CMAbout

Learn about ATTR-CM and uncover the differences between hereditary and wild-type ATTR-CM

About ATTR-CMWhat is ATTR-CM?The different types of ATTR-CM

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Diagnosis of ATTR-CMSigns and symptomsClinical cluesFormal diagnosis
Emerging treatmentsEducational resourcesEducational resources

Explore a range of educational resources to support the diagnosis of ATTR-CM

Educational resourcesExpert VideosDownloadable ResourcesOn Demand Congresses
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Click here for Vyndaqel®▼ (tafamidis) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

Recognising signs and symptoms of ATTR-CM

The diagnosis of ATTR-CM is often delayed or missed, resulting in an underdiagnosed cause of heart failure with preserved ejection fraction (HFpEF). Wild-type ATTR-CM accounts for 13-17% of HFpEF cases.1,2

  • In an ex-US study of 120 HFpEF patients 60 years or older, wild-type ATTR was confirmed in 13% (13.3%; 95% CI: 7.2–19.5) of the patients1
  • In a US study of 441 autopsied patients, 109 of whom had HFpEF, cardiac wild-type ATTR deposits were found in 17% of the patients2

Patients with wild-type ATTR and hereditary ATTR present with heart failure, particularly HFpEF and other cardiac symptoms.3-5

I Cardiac

  • Fatigue
  • Shortness of breath
  • Oedema
  • Arrhythmias
  • Heart failure with preserved ejection fraction (HFpEF)
  • Aortic stenosis
  • Orthostatic hypotension
  • Erectile dysfunction

| Soft tissue

    • Lumbar stenosis
    • Ruptured distal biceps tendon
    • Eye involvement – glaucoma, intravitreal deposition, scalloped pupils

    I GI

    • Diarrhoea
    • Constipation
    • Nausea
    • Early satiety

    | Neurologic

    • Bilateral carpal tunnel syndrome (CTS)
    • Sensory-motor polyneuropathy
    • Weakness
    Building the knowledge: One disease with many faces

    This is a series of animated, educational modules that outline key background information on ATTR amyloidosis. This video breaks down the various types of ATTR amyloidosis and the clinical clues that can raise suspicion of ATTR-CM.

    Consider the clinical clues and need for further testing Learn more LoadingSee other educational resources available Explore more Loading
    Reference:González-López E, Gallego-Delgado M, Guzzo-Merello G, et al. Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction. Eur Heart J. 2015; 36(38): 2585–2594. Mohammed SF, Mirzoyev SA, Edwards WD et al. Left ventricular amyloid deposition in patients with heart failure and preserved ejection fraction. JACC Heart Fail. 2014; 2(2): 113–122Connors LH, Sam F, Skinner M et al. Heart Failure Due to Age-Related Cardiac Amyloid Disease Associated With Wild-Type Transthyretin: A Prospective, Observational Cohort Study. Circulation. 2016; 133(3): 282–290.Maurer MS, Hanna M, Grogan M, et al. Genotype and Phenotype of Transthyretin Cardiac Amyloidosis. J Am Coll Cardiol. 2016; 68(2): 161–172.González-López E, López-Sainz Á, Garcia-Pavia P. Diagnosis and Treatment of Transthyretin Cardiac Amyloidosis. Progress and Hope. Rev Esp Cardiol (Engl Ed). 2017;70(11):991‐1004.Nativi-Nicolau J, Maurer MS. Amyloidosis cardiomyopathy: update in the diagnosis and treatment of the most common types. Curr Opin Cardiol. 2018; 33(5): 571–579.Sperry BW, Reyes BA, Ikram A et al. Tenosynovial and Cardiac Amyloidosis in Patients Undergoing Carpal Tunnel Release. J Am Coll Cardiol. 2018; 72(17): 2040-2050. Geller HI, Singh A, Alexander KM et al. Association Between Ruptured Distal Biceps Tendon and Wild-Type Transthyretin Cardiac Amyloidosis. JAMA. 2017; 318(10): 962–963.Galat A, Guellich A, Bodez D et al. Aortic stenosis and transthyretin cardiac amyloidosis: the chicken or the egg? Eur Heart J. 2016; 37(47): 3525–3531.Yanagisawa A, Ueda M, Sueyoshi T et al. Amyloid deposits derived from transthyretin in the ligamentum flavum as related to lumbar spinal canal stenosis. Mod Pathol. 2015; 28(2): 201–207.Witteles RM, Bokhari S, Damy T et al. Screening for Transthyretin Amyloid Cardiomyopathy in Everyday Practice. JACC Heart Fail. 2019; 7(8): 709–716.
    PP-VYN-GBR-0888. October 2021
    Quick Links
    View a range of educational resources to support the diagnosis of ATTR-CM

    Listen to our faculty of expert speakers and download resources including our interactive ATTR-CM Red Flags guide. You can also access and sign up to upcoming virtual events. 

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    PP-VYN-GBR-0729. May 2021

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