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Disease informationAdult Growth Hormone Deficiency (aGHD)Paediatric Growth Hormone Deficiency (pGHD)Small for Gestational Age (SGA)Prader-Willi SyndromeTurner SyndromeChronic Renal InsufficiencySupport & ResourcesVideosMaterials

Click here for Genotropin (somatropin) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

Small for Gestational AgePrevalence
  • Birth length and gestational age are rarely recorded in national databases, resulting in a lack of data on the incidence of small for gestational age (SGA) births1
  • Based on available data, it has been estimated that 2.3–10% of all infants are born SGA1

Children classified as born small for gestational age may have concurrent diagnoses such as familial short stature, Turner syndrome, or growth hormone deficiency. Approximately 10% of children born small for gestational age do not reach the normal height range. Those whose growth has not caught up by 4 years of age are candidates for treatment with growth hormone.2

Defining small for gestational age2

Various thresholds for height and weight at birth are used to define 'small for gestational age', the three most commonly used being:

  • a height at birth that is 2 standard deviations or more below the population average, or
  • a weight at birth that is 2 standard deviations or more below the population average, or
  • a weight at birth below the 10th percentile.

The international consensus definition of 'small for gestational age' is a length or weight at birth that is 2 standard deviations below ( −2 SD) the population average for birth or weight.

In addition to accurate measurements of a newborn's weight, length and head circumference, the diagnosis of small for gestational age requires accurate assessment of gestational age and valid data from a reference population.

Identification of SGA is important because infants are at an increased risk for3​​​​​​​:
  • Perinatal morbidity
  • Associated health problems, such as neurodevelopmental disorders
  • Persistent short stature
  • Metabolic alterations in later life

References:

Saenger P, et al. Endocrine Reviews 2007, 28: 219–251. NICE Guidance [TA188]. Human growth hormone (somatropin) for the treatment of growth failure in children. Clayton PE, et al. J Clin Endocrinol Metab 2007, 92: 804–810.
PP-GEN-GBR-1660. February 2023

Learn more about the 3 devices available for Genotropin patients on our Genotropin brand site

Genotropin for paediatric growth hormone disorders

Learn more about the paediatric indications and recommended dosing for Genotropin

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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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