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Disease informationAdult Growth Hormone Deficiency (aGHD)Paediatric Growth Hormone Deficiency (pGHD)Small for Gestational Age (SGA)Prader-Willi SyndromeTurner SyndromeChronic Renal InsufficiencySupport & ResourcesVideosMaterials

Click here for Genotropin (somatropin) Prescribing Information. Adverse event reporting information can be found at the bottom of the page.

Turner Syndrome and short statureTurner syndrome (TS) is a chromosomal disorder characterised by the complete or partial lack of one X chromosome in girls. The two most common clinical features are short stature and ovarian failure1.Not all girls with Turner syndrome will need treatment with growth hormone, but if the condition is untreated when indicated, girls with Turner syndrome will have a final adult height of 136–147 cm which on average is 20 cm shorter than other adult women1.Turner syndrome occurs in between 1 in 1500 and 1 in 2500 live female births1.Clinical presentation2,3
  • The presentation of TS varies throughout a patient’s life2 and the clinical appearance itself is highly variable3
  • At any age, TS may be difficult to recognise clinically because physical manifestations can be subtle2
At birth​​​​​​​3
  • Congenital lymphoedema, low hairline, nuchal skin and webbed neck may be present
  • Other features include small jaw, higharched palate, ptosis, down-slanting palpebral fissures, epicanthal folds, midface hypoplasia, prominent ears, dysplastic nails, broad chest with hypoplastic nipples, cubitus valgus, multiple pigmented nevi and short fourth metacarpals
Children and adults3
  • Difficulties with recurrent otitis media may lead to conductive hearing loss, while sensorineural hearing loss of unknown aetiology is common in adults
  • Intelligence is within the normal range, although difficulties with visual–spatial organisation and attention deficit are common
  • Autoimmune disorders, especially thyroiditis and (to a lesser extent) coeliac disease, occur with sufficient frequency to warrant screening

References:

NICE Guidance [TA188]. Human growth hormone (somatropin) for the treatment of growth failure in children.Morgan T. Am Fam Physician 2007, 76: 405–10.Pinhas-Hamiel O, Czernichow P, Zeitler P, Allen DB. Chapter 2: Normal growth and Growth Disorders. Pediatric Practice Endocrinology, 23–76.
PP-GEN-GBR-1661. February 2023
Genotropin for paediatric growth hormone disorders

Learn more about the paediatric indications and recommended dosing for Genotropin

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