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AboutAboutThe Burden of DiseaseRisk Factors of RADiagnosingDiagnosingSigns and SymptomsTreatmentTreatmentTreatment guidelinesPfizer Treatment OptionsSupporting ResourcesPatient Support & ResourcesPatient Support & ResourcesMaterialsVideos

Xeljanz®(tofacitinib citrate)Prescribing information, Enbrel®(etanercept) Prescribing information, Inflectra®(infliximab) Prescribing information and Maxtrex(methotrexate) Prescribing information. Adverse event reporting can be found at the bottom of the page.

The Burden of Rheumatoid Arthritis

Rheumatoid Arthritis impacts patients in their everyday lives. A number of studies have addressed this issue through patient self-reported questionnaires and interviews.25a 26a Some of the key findings of how RA impacts patients in their work-life, daily activities, emotions, and relationships are detailed below.


Patients with RA have reported being less productive due to RA.25b 27a In some cases, this included leaving the workforce due to RA, the primary reasons being fatigue, pain or stiffness, and mobility difficulties.26b Lost productivity contributes to the economic burden of RA.28

Daily Activities

Patients have reported difficulty performing valued life activities, including gardening, minor repairs, hobbies, activities with children, and physically strenuous leisure activities.29a


Patients with RA often have depression or depressive symptoms.27b Depression has been associated with increases in mortality, cardiovascular problems, and disability in patients with RA.27c


In a study of women with RA, patients reported concealing their pain from others and feeling that others do not understand their pain or fatigue.25c

Inflammation Disease Navigator

Click below to view the Immuno-navigator tool. An interactive tool to help you manage discussions with your patients . 

Visit the Navigator Tool

25 - Strand V, Wright GC, Bergman MJ, Tambiah J, Taylor PC. Patient expectations and perceptions of goal-setting strategies for disease management in rheumatoid arthritis. J Rheumatol. 2015; 42(11):2046-2054.
26 - Bertin P, Fagnani F, Duburcq A, et al. Impact of rheumatoid arthritis on career progression, productivity, and employability: the PRET Study. Joint Bone Spine. 2016; 83(1):47-52.
27 - Cutolo M, Kitas GD, van Riel PLCM. Burden of disease in treated rheumatoid arthritis patients: going beyond the joint. Semin Arthritis Rheum. 2014; 43:479-488.
28 - Zhu TY, Tam L-S, Li EK. Societal costs of rheumatoid arthritis in Hong Kong: a prevalence-based cost-of-illness study. Rheumatology. 2011; 50:1293-1301.
29 - Ahlstrand I, Bjӧrk M, Thyberg I, Falkmer T. Pain and difficulties performing valued life activities in women and men with rheumatoid arthritis. Clin Rheumatol. 2015; 34:1353-1362.

Learning Academy
Nutrition guide for patients with RA

A nutrition guide to help your patients manage their condition optimally.

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PP-XEL-GBR-4452. March 2023

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