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Information on how to access prescribing information and adverse event reporting can be found at the bottom of the page.Ulcerative Colitis


Crude incidence estimates between January 2000–31 December 2018. ‡Point prevalence estimates as on 31 December 20182 ​

UC=ulcerative colitis.​

1. Du L, Ha C. Gastroenterol Clin North Am. 2020;49(4):643−654. 2. Pasvol TJ, et al. BMJ Open. 2020;10(7):e036584. 
3. National Health Service (NHS). Patients Registered at a GP Practice September 2019. https://digital.nhs.uk/data-and-information/publications/statistical/patients-registered-at-a-gp-practice/september-2019. Accessed 26 July 2021. 
4. Høivik ML et al. Gut. 2013;62(3):368–375.
​​​​​​​5. Arnott I, et al. Inflamm Intest Dis. 2018; 2(4):189–199.

Disease activity and complications

CRC=colorectal cancer; EIM=extra-intestinal manifestation; UC=ulcerative colitis.​

Fumery M, et al. Clin Gastroenterol Hepatol. 2018;16(3):343−356.e3.

The interplay and determinants of incidence and prevalence of IBD and patient mortality rates
​​​​​​​

The true incidence of IBD is increasing due to factors associated with the Westernisation of society (dietary habits, antibiotic use, etc.)​

In parallel:​


  • Our ability to detect IBD has increased​
  • ​​​​​​​Our ability to better manage IBD, together with improvements in living standards generally, mean patients with IBD are living longer​


​​​​​​​In combination, these factors lead to an increase in the prevalence of IBD, and introduce the challenge of managing an increasingly ageing IBD population with potentially multiple comorbidities.

IBD=inflammatory bowel disease.​

Kaplan GG, Windsor JW. Nat Rev Gastroenterol Hepatol. 2021;18(1):56−66.

​​​​​​​Reproduced with permission from Kaplan GG, Windsor JW. 2021

UC prevalence and incidence: example data from NHS lothian, Scotland
Age at diagnosis for prevalent cases on 31/08/2018 overall. ‡Percentage prevalence is reported for age-appropriate population data derived from national records for Scotland; 2016-based projections for 2018.​

UC=ulcerative colitis.​

Jones JR, et al. Gut. 2019;68(11):1953−1960.

UC can lead to significant work disability 10 years after diagnosis† 
  • ​​​​​​​341 patients with UC followed up for 10 years (IBSEN population-based cohort)​
  • Relative risk for a disability allowance compared with the background population:​
  • All patients with UC = 1.80 (95% CI: 1.41–2.27)​
  • Patients with UC 30─39 years of age = 2.78 (95% CI: 1.44–5.38) 

Norwegian cohort study.​

CI=confidence interval; CRP=C-reactive protein; DA=disability allowance; ESR=erythrocyte sedimentation rate; IBSEN=Inflammatory Bowel in South Eastern Norway; UC=ulcerative colitis.​

Høivik ML et al. Gut. 2013;62(3):368–375.

Patients with UC are at significant risk of hospitalisation, colectomy and malignancy over time

ASCA=anti-Saccharomyces cerevisiæ antibody; CRC=colorectal cancer; CRP=C-reactive protein; ESR=erythrocyte sedimentation rate; pANCA=perinuclear anti-neutrophil cytoplasmic antibody; ​
UC=ulcerative colitis.​

Fumery M, et al. Clin Gastroenterol Hepatol. 2018;16(3):343−356.e3. 

Proportion of patients with UC undergoing colectomy has fallen since 2005

UC=ulcerative colitis.​

1. Jenkinson PW, et al. Colorectal Dis. 2020. doi: 10.1111/codi.15491. 2. Worley G, et al. Aliment Pharmacol Ther. 2020. doi: 10.1111/apt.16202.

Treatment challenges in UC

COVID-19=coronavirus disease of 2019; fCAL=faecal calprotectin; FMT=faecal microbial transplantation; RCT=randomised control trial; TDM=therapeutic drug monitoring; UC=ulcerative colitis.​

1. Danese S, et al. Dig Dis. 2019;37(4):266–283. 
2. Haberman Y, et al. Nat Commun. 2019;10(1):38. 
3. Peyrin-Biroulet L, et al. Am J Gastroenterol. 2015;110(9):1324−1338. ​
4. Lamb CA, et al. Gut. 2019;68(Suppl 3):s1−s106.  
5. Rahier JF, et al. J Crohns Colitis. 2014;8(6):443–468. 
6. Lees CW, et al. Gastroenterology. 2020;159(3):805−808. ​
7. Fumery M, et al. Clin Gastroenterol Hepatol. 2018;16(3):343−356.e3. 
​​​​​​​8. Crohn’s & Colitis Foundation. COVID-19 vaccines: What IBD patients & caregivers need to know. https://www.crohnscolitisfoundation.org/coronavirus/vaccines. Accessed 26 July 2021.

Find out more about Xeljanz as a treatment option for moderate to severe UCXeljanz brand site  Loading
PP-XEL-GBR-3607. April 2022
Prescribing information: Xeljanz (tofacitinib) | Pfizer PI index - UK (Version 2.0)

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

for MHRA Yellow Card in Google Play or Apple App Store


Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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