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AboutAboutTherapy Area OverviewRisk Factors of Ulcerative ColitisDiagnosingDiagnosingSigns and SymptomsComorbidities & PathophysiologyTreatmentTreatment guidelinesPfizer Treatment OptionsDisease NavigatorDisease NavigatorDisease NavigatorTreatmentTreatment guidelinesPfizer Treatment Options

Xeljanz®(tofacitinib citrate) Prescribing information and Inflectra®(infliximab) Prescribing information. Adverse event reporting can be found at the bottom of the page.

Ulcerative Colitis Signs and Symptoms

Ulcerative Colitis (UC) typically begins gradually and progresses for several weeks. Symptoms vary from person to person and can change over time as the disease progresses.1 Bloody diarrhea is the hallmark symptom of UC, but other gastrointestinal and general symptoms (also known as systemic symptoms) may also occur. 2-8

Gastrointestinal Symptoms
  • Rectal bleeding1
  • Diarrhea1
  • Abdominal pain1
  • Urgent need to move bowels1
  • Straining at stool7
Systemic Symptoms Associated With UC


  • Fever1
  • Loss of appetite1
  • Weight loss1
  • Fatigue
  • Night sweats1
  • Loss of normal menstrual cycle


Shared Symptoms in Ulcerative Colitis & Crohn's DiseaseShared Symptoms in Ulcerative Colitis & Crohn's DiseaseUlcerative Colitis
  • Rectal bleeding is common
  • May be associated with abdominal pain
  • Fistulas and strictures are rare
Crohn's Disease
  • Rectal bleeding is less common
  • Abdominal pain is common
  • Fistulas, strictures, and lesions around the anus are common
  • Nausea and vomiting
Shared between UC & CD
  • Diarrhea (blood or mucus)
  • Nocturnal diarrhea
  • Loss of control
  • Constipation
  • Pain or rectal bleeding with bowel movement
  • Severe bowel movement urgency
  • Abdominal cramps and pain

Common symptoms that characterise UC include rectal bleeding, diarrhea, abdominal pain, urgency, constant desire to pass stool and weight loss. UC and CD have many shared symptoms, but can also be differntiated clinically


Learning Academy
Inflammation Disease Navigator

Click below to view the Immuno-navigator tool. An interactive tool to help you manage discussions with your patients . 

Visit the Navigator Tool
Patient Support Materials (pdf)
Crohn’s and Colitis Foundation of America. The facts about inflammatory bowel diseases. 2014. [Document on the Internet]. 2014 Jan 1 [cited 2016 Dec 14]. Available from:ás I. Eckmann L, Talamini M, Baumgart DC, Sandborn WJ. Ulcerative colitis. Lancet. 2012; 380:1606-1619.Danese S, Fiocchi C. Ulcerative colitis. N Engl J Med. 2011; 365:1713-1725.American Society for Gastrointestinal Endoscopy. Media backgrounder: endoscopic procedures. [Document on the Internet]. 2014 Aug 1 [cited 2016 Dec 13]. Available from: de Chambrun G, Peyrin-Biroulet L, Lémann M, Colombel J-F. Clinical implications of mucosal healing for the management of IBD. Nat Rev Gastroenterol Hepatol. 2010; 7(1):15-29.Neurath MF. Cytokines in inflammatory bowel disease. Nat Rev Immunol. 2014; 14(5):329-342Feuerstein JD, Cheifetz AS. Ulcerative colitis: epidemiology, diagnosis, and management. Mayo Clin Proc. 2014; 89(11):1553-1563.Collins P, Rhodes J. Ulcerative colitis: diagnosis and management. BMJ. 2006; 333:340-343.
PP-IFA-GBR-0637. July 2023

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