This site contains promotional information intended only for healthcare professionals resident in the United Kingdom

Visit Pfizer Medical siteSearch

Menu

Close

Sign In or RegisterLog Out
Pfizer MedicinesTherapy AreasExplore ContentEventsVideosMaterialsFeatured ArticlesLet’s ConnectSupplyOff-contract claimsAlliance Healthcare

Example content

Menu

Close

AboutAboutTherapy Area OverviewRisk Factors of Ulcerative ColitisDiagnosingDiagnosingSigns and SymptomsComorbidities & PathophysiologyTreatmentTreatment guidelinesPfizer Treatment OptionsDisease NavigatorDisease NavigatorDisease NavigatorTreatmentTreatment guidelinesPfizer Treatment Options

Xeljanz®(tofacitinib citrate) Prescribing information and Inflectra®(infliximab) Prescribing information. Adverse event reporting can be found at the bottom of the page.

Ulcerative Colitis Signs and Symptoms

Ulcerative Colitis (UC) typically begins gradually and progresses for several weeks. Symptoms vary from person to person and can change over time as the disease progresses.1 Bloody diarrhea is the hallmark symptom of UC, but other gastrointestinal and general symptoms (also known as systemic symptoms) may also occur. 2-8
 

Gastrointestinal Symptoms
  • Rectal bleeding1
  • Diarrhea1
  • Abdominal pain1
  • Urgent need to move bowels1
  • Straining at stool7
Systemic Symptoms Associated With UC

 

  • Fever1
  • Loss of appetite1
  • Weight loss1
  • Fatigue
  • Night sweats1
  • Loss of normal menstrual cycle

 

Shared Symptoms in Ulcerative Colitis & Crohn's DiseaseShared Symptoms in Ulcerative Colitis & Crohn's DiseaseUlcerative Colitis
  • Rectal bleeding is common
  • May be associated with abdominal pain
  • Fistulas and strictures are rare
Crohn's Disease
  • Rectal bleeding is less common
  • Abdominal pain is common
  • Fistulas, strictures, and lesions around the anus are common
  • Nausea and vomiting
Shared between UC & CD
  • Diarrhea (blood or mucus)
  • Nocturnal diarrhea
  • Loss of control
  • Constipation
  • Pain or rectal bleeding with bowel movement
  • Severe bowel movement urgency
  • Abdominal cramps and pain


Common symptoms that characterise UC include rectal bleeding, diarrhea, abdominal pain, urgency, constant desire to pass stool and weight loss. UC and CD have many shared symptoms, but can also be differntiated clinically


References

 Learning Academy
Inflammation Disease Navigator

Click below to view the Immuno-navigator tool. An interactive tool to help you manage discussions with your patients . 

 Visit the Navigator Tool
Patient Support Materials (pdf)Crohn’s and Colitis Foundation of America. The facts about inflammatory bowel diseases. 2014. [Document on the Internet]. 2014 Jan 1 [cited 2016 Dec 14]. Available from: http://www.ccfa.org/assets/pdfs/updatedibdfactbook.pdf.Ordás I. Eckmann L, Talamini M, Baumgart DC, Sandborn WJ. Ulcerative colitis. Lancet. 2012; 380:1606-1619.Danese S, Fiocchi C. Ulcerative colitis. N Engl J Med. 2011; 365:1713-1725.American Society for Gastrointestinal Endoscopy. Media backgrounder: endoscopic procedures. [Document on the Internet]. 2014 Aug 1 [cited 2016 Dec 13]. Available from: http://www.asge.org/press/press.aspx?id=548Pineton de Chambrun G, Peyrin-Biroulet L, Lémann M, Colombel J-F. Clinical implications of mucosal healing for the management of IBD. Nat Rev Gastroenterol Hepatol. 2010; 7(1):15-29.Neurath MF. Cytokines in inflammatory bowel disease. Nat Rev Immunol. 2014; 14(5):329-342Feuerstein JD, Cheifetz AS. Ulcerative colitis: epidemiology, diagnosis, and management. Mayo Clin Proc. 2014; 89(11):1553-1563.Collins P, Rhodes J. Ulcerative colitis: diagnosis and management. BMJ. 2006; 333:340-343.
PP-IFA-GBR-0637. July 2023

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

for MHRA Yellow Card in Google Play or Apple App Store

 

Adverse events should also be reported to Pfizer Medical Information on 01304 616161

PfizerPro Account

To access further materials, resources and receive communication about medicines and vaccines promoted by Pfizer.

Sign In or RegisterAccountSign Out

This site is intended only for healthcare professionals resident in the United Kingdom. If you are a member of the public wishing to access information on a specific medicine, please visit www.medicines.org.uk/emc

 

This website is brought to you by Pfizer Limited, a company registered in England 

and Wales under No. 526209 with its registered office at Ramsgate Road, Sandwich, Kent, CT13 9NJ

 

Copyright © 2023 Pfizer Limited. All rights reserved.

 

VAT registration number GB201048427

PP-UNP-GBR-4885. May 2023
For UK Healthcare Professionals*

These pages are not intended for patients or for members of the general public. The healthcare professional web pages contain promotional content.

I confirm that I am a healthcare professional* resident in the United Kingdom.

If you select 'No', you will be redirected to Pfizer.co.uk where you will be able to access reference information on Pfizer's prescription medicines.

*The ABPI Code definition for healthcare professional is members of the medical, dental, pharmacy and nursing professionals and any other persons who in the course of their professional activities may administer, prescribe, purchase, recommend or supply a medicine.

PP-PFE-GBR-3863. November 2021

YesNo
You are now leaving PfizerPro​​​​​
​
​​​​​​​You are now leaving www.pfizerpro.co.uk. Links to external websites are provided as a resource to the viewer. This website is neither owned or controlled by Pfizer Ltd. 

Pfizer accepts no responsibility for the content or services of the linked site.​​​​​​​​​​​​​​

​​​​​​​PP-PFE-GBR-3858. November 2021​​​​​​​
​​​​​​​
You are now leaving PfizerPro
​​​​​​​
​​​​​​​You are now leaving www.pfizerpro.co.uk. Links to external websites are provided as a resource to the viewer. This website is neither owned nor controlled by Pfizer Ltd. 

Pfizer accepts no responsibility for the content or services of the linked site other than the information or other materials relating to ​​​​​Pfizer medicines or 
business which it has provided or reviewed.

PP-PFE-GBR-3859. November 2021
​​​​​​​