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AboutInfliximabWhat is infliximabInflammatory Bowel DiseaseMaximising patient outcomes with IBDBiosimilarsWhat is a biosimilarFuture of biosimilarsBiologic switchingINFLECTRA® Introducing INFLECTRA® Position statementsECCOEULARESPGHANDosing & safetyDosingIV dosingAdministration & storageAdministrationStorageSafety informationImportant safety informationConsiderations for SwitchingSwitching to InflectraSafety informationImportant safety informationSafety informationSafety informationClinical evidenceRandomised controlled trial evidenceSummary: randomised controlled trial evidenceReal-world experienceSummary: real-world evidenceSupporting ResourcesVideosMaterialsPatient Support


Inflectra®(infliximab) Prescribing Information. Adverse events reporting information can be found at the bottom of the page.

 

What is infliximab?Infliximab infusion therapy is an established treatment for many inflammatory diseases1-7Infliximab has more than 20 years of clinical experience as an infusion therapy1

INFLECTRA has demonstrated comparable efficacy and safety to Remicade® in rigorous clinical studies for RA and AS and, via extrapolation, is licensed for all the same clinical indications as Remicade®.11-13

Appropriate use of infliximab infusion therapy is supported by clinical guidelines in CD/UC, paediatric CD/UC, RA, PsA and AS‡14-20

Infliximab mechanism of action
Watch how infliximab blocks the functional activity of TNF-a
 Find out more about Inflectra and Inflammatory Bowel Disease for your patients with UC and CD.Loading

Example

Guidelines of the Assessment of Spondyloarthritis International Society (AS), the European Crohn’s and Colitis Organisation (CD, UC), the European League Against Rheumatism (AS, PsA, RA), and the European Society for Paediatric Gastroenterology Hepatology and Nutrition (paediatric CD, paediatric UC).AS, Ankylosing spondylitis; CD, Crohn’s disease; PsA, Psoriatic arthritis; PsO, Psoriasis; RA, Rheumatoid arthritis; TNFi, Tumour necrosis factor inhibitor; UC, Ulcerative colitis.

Return to our Inflectra homepage to explore more about Infliximab 

 

References:Melsheimer R, et al. Biologics 2019;13:139-78. Danese S, et al. Aliment Pharmacol Ther 2011;33:857-69.Moss AC. Gastroenterol Rep 2015;3(1):63-8. Guariso G, Gasparetto M. World J Gastroenterol 2017;23:5469-85.Aardoom MA, et al. Int J Mol Sci 2019;20:2529. Doi: 10.3390/ijms20102529.Smolen JS, Emery P. Arthritis Res Ther 2011;13(Suppl 1):S2.Remicade™ Summary of Product Characteristics.Center for Drug Evaluation and Research. 2005. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/103772Orig1s5113.pdfRemicade™ Scientific Discussion. January 2006. Available at: https://www.ema.europa.eu/en/documents/scientific-discussion-variation/remicade-h-c-240-ii-0065-epar-scientific-discussion-variation_en.pdf. Accessed March 2021.Centocor, Inc. [Public Release: 7 November 2007]. Available at: https://www.fdanews.com/articles/100766-remicade-becomes-first-anti-tnf-biologic-therapy-to-treat-1-million-patients. Accessed March 2021.European Public Assessment Report: Inflectra [online]. 2013. https://www.ema.europa.eu/docs/en_GB/document_library/EPAR__Public_assessment_report/human/002778/WC500151490.pdfInflectra Summary of Product Characteristics.Guidelines on Similar Biological Medicinal Products Containing Monoclonal Antibodies -Non-Clinical and Clinical Issues [online]. 2012 [viewed: February 2021] http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2012/06/WC500128686.pdfGomollon F, et al. J Crohns Colitis 2017;11(1):3-25.Turner D, et al. jpgN 2018;67:257-91.Turner D, et al. jpgN 2018;67:292-310.Ruemmele FM, et al. J Crohns Colitis 2014;8:1179-207.Smolen JS, et al. Ann Rheum Dis 2020;0:1-15.Gossec L, et al. Ann Rheum Dis 2016;75:499-510.van der Heijde D, et al. Ann Rheum Dis 2017;76:978-91. 
Infliximab
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Learn more about dosing and safety information for Inflectra
PP-IFA-GBR-0610. April 2023

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard or search 

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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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