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Pfizer MedicinesTherapy AreasExplore ContentEventsVideosMaterialsFeatured ArticlesLet’s ConnectSupplyAlliance HealthcareOff-contract claims

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EMBRACA Study
EMBRACA StudyEfficacy OutcomesSafetyPROs
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TALZENNA efficacyPrimary endpoint & subgroup analysisSecondary endpoints: ORRSecondary endpoint: OSExploratory endpoints: DoR & TTRTALZENNA safetySafety and tolerabillityAdverse eventsHematologic/Nonhematologic AEsPatient-reported outcomes with TALZENNAPatient-reported outcomesGHS/QoLBreast symptoms
Talzenna MoA

The content of this website has been produced in line with the Talzenna® Summary of Product Characteristics for Great Britain and Northern Ireland. Talzenna® (talazoparib) Prescribing Information for Great Britain and Northern Ireland click here.  Adverse event reporting information can be found at the bottom of the page.

TALZENNA® is indicated as monotherapy for the treatment of adult patients with germline BRCA1/2-mutations, who have HER2-negative locally advanced or metastatic breast cancer
  • Patients should have been previously treated with an anthracycline and/or a taxane in the (neo)adjuvant, locally advanced or metastatic setting unless patients were not suitable for these treatments1
  • Patients with hormone receptor (HR)-positive breast cancer should have been treated with a prior endocrine-based therapy, or be considered unsuitable for endocrine-based therapy1
EMBRACA study: Efficacy outcomes

EMBRACA is a Phase III, open-label study of PARP inhibitor monotherapy, TALZENNA, versus chemotherapy* in gBRCA1/2-mutated HER2− LA/mBC. PFS was the primary endpoint in the EMBRACA study, with OS as a key secondary endpoint2

Find out more
EMBRACA study: Patient-reported outcomes (PROs)

GHS/QOL and breast symptoms were exploratory endpoints in the Phase 3 EMBRACA study2

See the results 
EMBRACA study: Safety profile 

TALZENNA® has a generally manageable safety profile1,2

Safety profile information
Dosing

Once-daily, oral dosing1

Learn more 
*Physician’s choice of chemotherapy included capecitabine, eribulin, gemcitabine or vinorelbine.
BRCA=breast cancer susceptibility gene; CI=confidence interval; GHS=global health status; HER2=human epidermal growth factor receptor 2; HR=hormone receptor; QoL=quality of life; PRO=patient-reported outcome
References:TALZENNA® Summary of Product Characteristics for Great Britain click here. TALZENNA® Summary of Product Characteristics for Northern Ireland click here.Litton JK, et al. Ann Oncol. 2020;31(11):1526-2535.
PP-TAL-GBR-0231. August 2024

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Adverse events should also be reported to Pfizer Medical Information on 01304 616161

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